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Page 1
Attenuation of mechanical pain hypersensitivity by treatment with Peptide5, a connexin-43 mimetic peptide, involves inhibition of NLRP3 inflammasome in nerve-injured mice.
Tonkin RS, Bowles C, Perera CJ, Keating BA, Makker PGS, Duffy SS, Lees JG, Tran C, Don AS, Fath T, Liu L, O'Carroll SJ, Nicholson LFB, Green CR, Gorrie C, Moalem-Taylor G. Tonkin RS, et al. Among authors: don as. Exp Neurol. 2018 Feb;300:1-12. doi: 10.1016/j.expneurol.2017.10.016. Epub 2017 Oct 18. Exp Neurol. 2018. PMID: 29055716
A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism.
Turner N, Lim XY, Toop HD, Osborne B, Brandon AE, Taylor EN, Fiveash CE, Govindaraju H, Teo JD, McEwen HP, Couttas TA, Butler SM, Das A, Kowalski GM, Bruce CR, Hoehn KL, Fath T, Schmitz-Peiffer C, Cooney GJ, Montgomery MK, Morris JC, Don AS. Turner N, et al. Among authors: don as. Nat Commun. 2018 Aug 21;9(1):3165. doi: 10.1038/s41467-018-05613-7. Nat Commun. 2018. PMID: 30131496 Free PMC article.
Sphingosine Kinase 2 Potentiates Amyloid Deposition but Protects against Hippocampal Volume Loss and Demyelination in a Mouse Model of Alzheimer's Disease.
Lei M, Teo JD, Song H, McEwen HP, Yup Lee J, Couttas TA, Duncan T, Chesworth R, Bertz J, Przybyla M, Van Eersel J, Heng B, Guillemin GJ, Ittner LM, Fath T, Garner B, Ittner A, Karl T, Don AS. Lei M, et al. Among authors: don as. J Neurosci. 2019 Nov 27;39(48):9645-9659. doi: 10.1523/JNEUROSCI.0524-19.2019. Epub 2019 Oct 22. J Neurosci. 2019. PMID: 31641049 Free PMC article.
Regulation of hepatic insulin signaling and glucose homeostasis by sphingosine kinase 2.
Aji G, Huang Y, Ng ML, Wang W, Lan T, Li M, Li Y, Chen Q, Li R, Yan S, Tran C, Burchfield JG, Couttas TA, Chen J, Chung LH, Liu D, Wadham C, Hogg PJ, Gao X, Vadas MA, Gamble JR, Don AS, Xia P, Qi Y. Aji G, et al. Among authors: don as. Proc Natl Acad Sci U S A. 2020 Sep 29;117(39):24434-24442. doi: 10.1073/pnas.2007856117. Epub 2020 Sep 11. Proc Natl Acad Sci U S A. 2020. PMID: 32917816 Free PMC article.
Ablation of sphingosine kinase 2 suppresses fatty liver-associated hepatocellular carcinoma via downregulation of ceramide transfer protein.
Liu XT, Chung LH, Liu D, Chen J, Huang Y, Teo JD, Han XD, Zhao Y, Guan FHX, Tran C, Lee JY, Couttas TA, Liu K, McCaughan GW, Gorrell MD, Don AS, Zhang S, Qi Y. Liu XT, et al. Among authors: don as. Oncogenesis. 2022 Nov 4;11(1):67. doi: 10.1038/s41389-022-00444-0. Oncogenesis. 2022. PMID: 36333295 Free PMC article.
Targeting the SphK1/S1P/PFKFB3 axis suppresses hepatocellular carcinoma progression by disrupting glycolytic energy supply that drives tumor angiogenesis.
Liu XT, Huang Y, Liu D, Jiang YC, Zhao M, Chung LH, Han XD, Zhao Y, Chen J, Coleman P, Ting KK, Tran C, Su Y, Dennis CV, Bhatnagar A, Liu K, Don AS, Vadas MA, Gorrell MD, Zhang S, Murray M, Kavurma MM, McCaughan GW, Gamble JR, Qi Y. Liu XT, et al. Among authors: don as. J Transl Med. 2024 Jan 10;22(1):43. doi: 10.1186/s12967-023-04830-z. J Transl Med. 2024. PMID: 38200582 Free PMC article.
90 results