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Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma.
Ducker GS, Ghergurovich JM, Mainolfi N, Suri V, Jeong SK, Hsin-Jung Li S, Friedman A, Manfredi MG, Gitai Z, Kim H, Rabinowitz JD. Ducker GS, et al. Among authors: ghergurovich jm. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11404-11409. doi: 10.1073/pnas.1706617114. Epub 2017 Oct 9. Proc Natl Acad Sci U S A. 2017. PMID: 29073064 Free PMC article.
Defective respiration and one-carbon metabolism contribute to impaired naïve T cell activation in aged mice.
Ron-Harel N, Notarangelo G, Ghergurovich JM, Paulo JA, Sage PT, Santos D, Satterstrom FK, Gygi SP, Rabinowitz JD, Sharpe AH, Haigis MC. Ron-Harel N, et al. Among authors: ghergurovich jm. Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):13347-13352. doi: 10.1073/pnas.1804149115. Epub 2018 Dec 10. Proc Natl Acad Sci U S A. 2018. PMID: 30530686 Free PMC article.
Methionine synthase supports tumour tetrahydrofolate pools.
Ghergurovich JM, Xu X, Wang JZ, Yang L, Ryseck RP, Wang L, Rabinowitz JD. Ghergurovich JM, et al. Nat Metab. 2021 Nov;3(11):1512-1520. doi: 10.1038/s42255-021-00465-w. Epub 2021 Nov 18. Nat Metab. 2021. PMID: 34799699 Free PMC article.
Serine Catabolism Feeds NADH when Respiration Is Impaired.
Yang L, Garcia Canaveras JC, Chen Z, Wang L, Liang L, Jang C, Mayr JA, Zhang Z, Ghergurovich JM, Zhan L, Joshi S, Hu Z, McReynolds MR, Su X, White E, Morscher RJ, Rabinowitz JD. Yang L, et al. Among authors: ghergurovich jm. Cell Metab. 2020 Apr 7;31(4):809-821.e6. doi: 10.1016/j.cmet.2020.02.017. Epub 2020 Mar 17. Cell Metab. 2020. PMID: 32187526 Free PMC article.
A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway.
Ghergurovich JM, García-Cañaveras JC, Wang J, Schmidt E, Zhang Z, TeSlaa T, Patel H, Chen L, Britt EC, Piqueras-Nebot M, Gomez-Cabrera MC, Lahoz A, Fan J, Beier UH, Kim H, Rabinowitz JD. Ghergurovich JM, et al. Nat Chem Biol. 2020 Jul;16(7):731-739. doi: 10.1038/s41589-020-0533-x. Epub 2020 May 11. Nat Chem Biol. 2020. PMID: 32393898 Free PMC article.
17 results