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83 results

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A phase 2, open-label, multi-center study of amuvatinib in combination with platinum etoposide chemotherapy in platinum-refractory small cell lung cancer patients.
Byers LA, Horn L, Ghandi J, Kloecker G, Owonikoko T, Waqar SN, Krzakowski M, Cardnell RJ, Fujimoto J, Taverna P, Azab M, Camidge DR. Byers LA, et al. Among authors: taverna p. Oncotarget. 2017 Aug 3;8(46):81441-81454. doi: 10.18632/oncotarget.19888. eCollection 2017 Oct 6. Oncotarget. 2017. PMID: 29113403 Free PMC article.
Safety and tolerability of guadecitabine (SGI-110) in patients with myelodysplastic syndrome and acute myeloid leukaemia: a multicentre, randomised, dose-escalation phase 1 study.
Issa JJ, Roboz G, Rizzieri D, Jabbour E, Stock W, O'Connell C, Yee K, Tibes R, Griffiths EA, Walsh K, Daver N, Chung W, Naim S, Taverna P, Oganesian A, Hao Y, Lowder JN, Azab M, Kantarjian H. Issa JJ, et al. Among authors: taverna p. Lancet Oncol. 2015 Sep;16(9):1099-1110. doi: 10.1016/S1470-2045(15)00038-8. Epub 2015 Aug 19. Lancet Oncol. 2015. PMID: 26296954 Free PMC article. Clinical Trial.
Epigenetics meets immune checkpoints.
Covre A, Coral S, Di Giacomo AM, Taverna P, Azab M, Maio M. Covre A, et al. Among authors: taverna p. Semin Oncol. 2015 Jun;42(3):506-13. doi: 10.1053/j.seminoncol.2015.02.003. Epub 2015 Feb 14. Semin Oncol. 2015. PMID: 25965370 Review.
Refractory testicular germ cell tumors are highly sensitive to the second generation DNA methylation inhibitor guadecitabine.
Albany C, Hever-Jardine MP, von Herrmann KM, Yim CY, Tam J, Warzecha JM, Shin L, Bock SE, Curran BS, Chaudhry AS, Kim F, Sandusky GE, Taverna P, Freemantle SJ, Christensen BC, Einhorn LH, Spinella MJ. Albany C, et al. Among authors: taverna p. Oncotarget. 2017 Jan 10;8(2):2949-2959. doi: 10.18632/oncotarget.13811. Oncotarget. 2017. PMID: 27936464 Free PMC article.
The novel, small-molecule DNA methylation inhibitor SGI-110 as an ovarian cancer chemosensitizer.
Fang F, Munck J, Tang J, Taverna P, Wang Y, Miller DF, Pilrose J, Choy G, Azab M, Pawelczak KS, VanderVere-Carozza P, Wagner M, Lyons J, Matei D, Turchi JJ, Nephew KP. Fang F, et al. Among authors: taverna p. Clin Cancer Res. 2014 Dec 15;20(24):6504-16. doi: 10.1158/1078-0432.CCR-14-1553. Epub 2014 Oct 14. Clin Cancer Res. 2014. PMID: 25316809 Free PMC article.
SGI-110: DNA Methyltransferase Inhibitor Oncolytic.
Griffiths EA, Choy G, Redkar S, Taverna P, Azab M, Karpf AR. Griffiths EA, et al. Among authors: taverna p. Drugs Future. 2013 Aug;38(8):535-543. Drugs Future. 2013. PMID: 26190889 Free PMC article.
Efficacy and epigenetic interactions of novel DNA hypomethylating agent guadecitabine (SGI-110) in preclinical models of hepatocellular carcinoma.
Jueliger S, Lyons J, Cannito S, Pata I, Pata P, Shkolnaya M, Lo Re O, Peyrou M, Villarroya F, Pazienza V, Rappa F, Cappello F, Azab M, Taverna P, Vinciguerra M. Jueliger S, et al. Among authors: taverna p. Epigenetics. 2016 Oct 2;11(10):709-720. doi: 10.1080/15592294.2016.1214781. Epub 2016 Sep 20. Epigenetics. 2016. PMID: 27646854 Free PMC article.
83 results