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287 results

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Cancer-Associated Fibroblasts Neutralize the Anti-tumor Effect of CSF1 Receptor Blockade by Inducing PMN-MDSC Infiltration of Tumors.
Kumar V, Donthireddy L, Marvel D, Condamine T, Wang F, Lavilla-Alonso S, Hashimoto A, Vonteddu P, Behera R, Goins MA, Mulligan C, Nam B, Hockstein N, Denstman F, Shakamuri S, Speicher DW, Weeraratna AT, Chao T, Vonderheide RH, Languino LR, Ordentlich P, Liu Q, Xu X, Lo A, Puré E, Zhang C, Loboda A, Sepulveda MA, Snyder LA, Gabrilovich DI. Kumar V, et al. Among authors: speicher dw. Cancer Cell. 2017 Nov 13;32(5):654-668.e5. doi: 10.1016/j.ccell.2017.10.005. Cancer Cell. 2017. PMID: 29136508 Free PMC article.
Syntaphilin Ubiquitination Regulates Mitochondrial Dynamics and Tumor Cell Movements.
Seo JH, Agarwal E, Bryant KG, Caino MC, Kim ET, Kossenkov AV, Tang HY, Languino LR, Gabrilovich DI, Cohen AR, Speicher DW, Altieri DC. Seo JH, et al. Among authors: speicher dw. Cancer Res. 2018 Aug 1;78(15):4215-4228. doi: 10.1158/0008-5472.CAN-18-0595. Epub 2018 Jun 13. Cancer Res. 2018. PMID: 29898993 Free PMC article.
Peroxynitrite in the tumor microenvironment changes the profile of antigens allowing escape from cancer immunotherapy.
Tcyganov EN, Sanseviero E, Marvel D, Beer T, Tang HY, Hembach P, Speicher DW, Zhang Q, Donthireddy LR, Mostafa A, Tsyganova S, Pisarev V, Laufer T, Ignatov D, Ferrone S, Meyer C, Maby-El Hajjami H, Speiser DE, Altiok S, Antonia S, Xu X, Xu W, Zheng C, Schuchter LM, Amaravadi RK, Mitchell TC, Karakousis GC, Yuan Z, Montaner LJ, Celis E, Gabrilovich DI. Tcyganov EN, et al. Among authors: speicher dw. Cancer Cell. 2022 Oct 10;40(10):1173-1189.e6. doi: 10.1016/j.ccell.2022.09.001. Cancer Cell. 2022. PMID: 36220073 Free PMC article.
MFF Regulation of Mitochondrial Cell Death Is a Therapeutic Target in Cancer.
Seo JH, Chae YC, Kossenkov AV, Lee YG, Tang HY, Agarwal E, Gabrilovich DI, Languino LR, Speicher DW, Shastrula PK, Storaci AM, Ferrero S, Gaudioso G, Caroli M, Tosi D, Giroda M, Vaira V, Rebecca VW, Herlyn M, Xiao M, Fingerman D, Martorella A, Skordalakes E, Altieri DC. Seo JH, et al. Among authors: speicher dw. Cancer Res. 2019 Dec 15;79(24):6215-6226. doi: 10.1158/0008-5472.CAN-19-1982. Epub 2019 Oct 3. Cancer Res. 2019. PMID: 31582380 Free PMC article.
Changes in Aged Fibroblast Lipid Metabolism Induce Age-Dependent Melanoma Cell Resistance to Targeted Therapy via the Fatty Acid Transporter FATP2.
Alicea GM, Rebecca VW, Goldman AR, Fane ME, Douglass SM, Behera R, Webster MR, Kugel CH 3rd, Ecker BL, Caino MC, Kossenkov AV, Tang HY, Frederick DT, Flaherty KT, Xu X, Liu Q, Gabrilovich DI, Herlyn M, Blair IA, Schug ZT, Speicher DW, Weeraratna AT. Alicea GM, et al. Among authors: speicher dw. Cancer Discov. 2020 Sep;10(9):1282-1295. doi: 10.1158/2159-8290.CD-20-0329. Epub 2020 Jun 4. Cancer Discov. 2020. PMID: 32499221 Free PMC article.
A Novel Inhibitor of HSP70 Induces Mitochondrial Toxicity and Immune Cell Recruitment in Tumors.
Barnoud T, Leung JC, Leu JI, Basu S, Poli ANR, Parris JLD, Indeglia A, Martynyuk T, Good M, Gnanapradeepan K, Sanseviero E, Moeller R, Tang HY, Cassel J, Kossenkov AV, Liu Q, Speicher DW, Gabrilovich DI, Salvino JM, George DL, Murphy ME. Barnoud T, et al. Among authors: speicher dw. Cancer Res. 2020 Dec 1;80(23):5270-5281. doi: 10.1158/0008-5472.CAN-20-0397. Epub 2020 Oct 6. Cancer Res. 2020. PMID: 33023943 Free PMC article.
Mitochondrial Akt Regulation of Hypoxic Tumor Reprogramming.
Chae YC, Vaira V, Caino MC, Tang HY, Seo JH, Kossenkov AV, Ottobrini L, Martelli C, Lucignani G, Bertolini I, Locatelli M, Bryant KG, Ghosh JC, Lisanti S, Ku B, Bosari S, Languino LR, Speicher DW, Altieri DC. Chae YC, et al. Among authors: speicher dw. Cancer Cell. 2016 Aug 8;30(2):257-272. doi: 10.1016/j.ccell.2016.07.004. Cancer Cell. 2016. PMID: 27505672 Free PMC article.
Exosomal αvβ6 integrin is required for monocyte M2 polarization in prostate cancer.
Lu H, Bowler N, Harshyne LA, Craig Hooper D, Krishn SR, Kurtoglu S, Fedele C, Liu Q, Tang HY, Kossenkov AV, Kelly WK, Wang K, Kean RB, Weinreb PH, Yu L, Dutta A, Fortina P, Ertel A, Stanczak M, Forsberg F, Gabrilovich DI, Speicher DW, Altieri DC, Languino LR. Lu H, et al. Among authors: speicher dw. Matrix Biol. 2018 Sep;70:20-35. doi: 10.1016/j.matbio.2018.03.009. Epub 2018 Mar 9. Matrix Biol. 2018. PMID: 29530483 Free PMC article.
287 results