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Page 1
Risk stratification after paracetamol overdose using mechanistic biomarkers: results from two prospective cohort studies.
Dear JW, Clarke JI, Francis B, Allen L, Wraight J, Shen J, Dargan PI, Wood D, Cooper J, Thomas SHL, Jorgensen AL, Pirmohamed M, Park BK, Antoine DJ. Dear JW, et al. Among authors: clarke ji. Lancet Gastroenterol Hepatol. 2018 Feb;3(2):104-113. doi: 10.1016/S2468-1253(17)30266-2. Epub 2017 Nov 14. Lancet Gastroenterol Hepatol. 2018. PMID: 29146439 Free PMC article.
Bile acid-induced necrosis in primary human hepatocytes and in patients with obstructive cholestasis.
Woolbright BL, Dorko K, Antoine DJ, Clarke JI, Gholami P, Li F, Kumer SC, Schmitt TM, Forster J, Fan F, Jenkins RE, Park BK, Hagenbuch B, Olyaee M, Jaeschke H. Woolbright BL, et al. Among authors: clarke ji. Toxicol Appl Pharmacol. 2015 Mar 15;283(3):168-77. doi: 10.1016/j.taap.2015.01.015. Epub 2015 Jan 28. Toxicol Appl Pharmacol. 2015. PMID: 25636263 Free PMC article.
Comprehensive microRNA profiling in acetaminophen toxicity identifies novel circulating biomarkers for human liver and kidney injury.
Vliegenthart AD, Shaffer JM, Clarke JI, Peeters LE, Caporali A, Bateman DN, Wood DM, Dargan PI, Craig DG, Moore JK, Thompson AI, Henderson NC, Webb DJ, Sharkey J, Antoine DJ, Park BK, Bailey MA, Lader E, Simpson KJ, Dear JW. Vliegenthart AD, et al. Among authors: clarke ji. Sci Rep. 2015 Oct 22;5:15501. doi: 10.1038/srep15501. Sci Rep. 2015. PMID: 26489516 Free PMC article.
A novel high mobility group box 1 neutralizing chimeric antibody attenuates drug-induced liver injury and postinjury inflammation in mice.
Lundbäck P, Lea JD, Sowinska A, Ottosson L, Fürst CM, Steen J, Aulin C, Clarke JI, Kipar A, Klevenvall L, Yang H, Palmblad K, Park BK, Tracey KJ, Blom AM, Andersson U, Antoine DJ, Erlandsson Harris H. Lundbäck P, et al. Among authors: clarke ji. Hepatology. 2016 Nov;64(5):1699-1710. doi: 10.1002/hep.28736. Epub 2016 Sep 1. Hepatology. 2016. PMID: 27474782 Free PMC article.
Circulating acetaminophen metabolites are toxicokinetic biomarkers of acute liver injury.
Vliegenthart A, Kimmitt RA, Seymour JH, Homer NZ, Clarke JI, Eddleston M, Gray A, Wood DM, Dargan PI, Cooper JG, Antoine DJ, Webb DJ, Lewis SC, Bateman DN, Dear JW. Vliegenthart A, et al. Among authors: clarke ji. Clin Pharmacol Ther. 2017 Apr;101(4):531-540. doi: 10.1002/cpt.541. Epub 2016 Nov 30. Clin Pharmacol Ther. 2017. PMID: 27770431 Free PMC article.
19 results