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Association of a variant in the gene encoding for ERV1/ChemR23 with reduced inflammation in visceral adipose tissue from morbidly obese individuals.
López-Vicario C, Rius B, Alcaraz-Quiles J, González-Périz A, Martínez-Puchol AI, Casulleras M, Duran-Güell M, Ibarzabal A, Corcelles R, Laguna-Fernández A, Back M, Titos E, Clària J. López-Vicario C, et al. Among authors: casulleras m. Sci Rep. 2017 Nov 16;7(1):15724. doi: 10.1038/s41598-017-15951-z. Sci Rep. 2017. PMID: 29146976 Free PMC article.
Polymorphisms in the IL-1 gene cluster influence systemic inflammation in patients at risk for acute-on-chronic liver failure.
Alcaraz-Quiles J, Titos E, Casulleras M, Pavesi M, López-Vicario C, Rius B, Lopategi A, de Gottardi A, Graziadei I, Gronbaek H, Ginès P, Bernardi M, Arroyo V, Clària J. Alcaraz-Quiles J, et al. Among authors: casulleras m. Hepatology. 2017 Jan;65(1):202-216. doi: 10.1002/hep.28896. Epub 2016 Nov 28. Hepatology. 2017. PMID: 27775822
The specialized proresolving lipid mediator maresin 1 protects hepatocytes from lipotoxic and hypoxia-induced endoplasmic reticulum stress.
Rius B, Duran-Güell M, Flores-Costa R, López-Vicario C, Lopategi A, Alcaraz-Quiles J, Casulleras M, Lozano JJ, Titos E, Clària J. Rius B, et al. Among authors: casulleras m. FASEB J. 2017 Dec;31(12):5384-5398. doi: 10.1096/fj.201700394R. Epub 2017 Aug 2. FASEB J. 2017. PMID: 28768719 Free article.
Together, these findings describe the ability of MaR1 to oppose ER stress in liver cells under conditions frequently encountered in NAFLD.-Rius, B., Duran-Guell, M., Flores-Costa, R., Lopez-Vicario, C., Lopategi, A., Alcaraz-Quiles, J., Casulleras, M., Lozano …
Together, these findings describe the ability of MaR1 to oppose ER stress in liver cells under conditions frequently encountered in NAFLD.-R …
The soluble guanylate cyclase stimulator IW-1973 prevents inflammation and fibrosis in experimental non-alcoholic steatohepatitis.
Flores-Costa R, Alcaraz-Quiles J, Titos E, López-Vicario C, Casulleras M, Duran-Güell M, Rius B, Diaz A, Hall K, Shea C, Sarno R, Currie M, Masferrer JL, Clària J. Flores-Costa R, et al. Among authors: casulleras m. Br J Pharmacol. 2018 Mar;175(6):953-967. doi: 10.1111/bph.14137. Epub 2018 Jan 31. Br J Pharmacol. 2018. PMID: 29281143 Free PMC article.
Oxidized Albumin Triggers a Cytokine Storm in Leukocytes Through P38 Mitogen-Activated Protein Kinase: Role in Systemic Inflammation in Decompensated Cirrhosis.
Alcaraz-Quiles J, Casulleras M, Oettl K, Titos E, Flores-Costa R, Duran-Güell M, López-Vicario C, Pavesi M, Stauber RE, Arroyo V, Clària J. Alcaraz-Quiles J, et al. Among authors: casulleras m. Hepatology. 2018 Nov;68(5):1937-1952. doi: 10.1002/hep.30135. Epub 2018 Oct 13. Hepatology. 2018. PMID: 30070728 Free article.
Leukocytes from obese individuals exhibit an impaired SPM signature.
López-Vicario C, Titos E, Walker ME, Alcaraz-Quiles J, Casulleras M, Durán-Güell M, Flores-Costa R, Pérez-Romero N, Forné M, Dalli J, Clària J. López-Vicario C, et al. Among authors: casulleras m. FASEB J. 2019 Jun;33(6):7072-7083. doi: 10.1096/fj.201802587R. Epub 2019 Mar 6. FASEB J. 2019. PMID: 30840838 Free article.
These data provide proof of concept that administration of intermediate precursors of SPM biosynthesis (e.g., 17-HDHA) could be more efficient in overriding impaired formation of these proresolving lipid mediators in conditions characterized by dysfunctional LOX activity, such as …
These data provide proof of concept that administration of intermediate precursors of SPM biosynthesis (e.g., 17-HDHA) could be more efficie …
Small fragments of hyaluronan are increased in individuals with obesity and contribute to low-grade inflammation through TLR-mediated activation of innate immune cells.
Romo M, López-Vicario C, Pérez-Romero N, Casulleras M, Martínez-Puchol AI, Sánchez B, Flores-Costa R, Alcaraz-Quiles J, Duran-Güell M, Ibarzábal A, Espert JJ, Clària J, Titos E. Romo M, et al. Among authors: casulleras m. Int J Obes (Lond). 2022 Nov;46(11):1960-1969. doi: 10.1038/s41366-022-01187-z. Epub 2022 Jul 27. Int J Obes (Lond). 2022. PMID: 35896710 Free PMC article.
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