Toll L - Search Results

1

Highly Selective and Potent α4β2 nAChR Antagonist Inhibits Nicotine Self-Administration and Reinstatement in Rats.

Wu J, Cippitelli A, Zhang Y, Debevec G, Schoch J, Ozawa A, Yu Y, Liu H, Chen W, Houghten RA, Welmaker GS, Giulianotti MA, Toll L. Wu J, et al. Among authors: toll l. J Med Chem. 2017 Dec 28;60(24):10092-10104. doi: 10.1021/acs.jmedchem.7b01250. Epub 2017 Dec 13. J Med Chem. 2017. PMID: 29178785 Free PMC article.

2

Potent μ-Opioid Receptor Agonists from Cyclic Peptides Tyr-c[D-Lys-Xxx-Tyr-Gly]: Synthesis, Biological, and Structural Evaluation.

Li Y, Cazares M, Wu J, Houghten RA, Toll L, Dooley C. Li Y, et al. Among authors: toll l. J Med Chem. 2016 Feb 11;59(3):1239-45. doi: 10.1021/acs.jmedchem.5b01899. Epub 2016 Jan 29. J Med Chem. 2016. PMID: 26789491

3

Scaffold ranking and positional scanning utilized in the discovery of nAChR-selective compounds suitable for optimization studies.

Wu J, Zhang Y, Maida LE, Santos RG, Welmaker GS, LaVoi TM, Nefzi A, Yu Y, Houghten RA, Toll L, Giulianotti MA. Wu J, et al. Among authors: toll l. J Med Chem. 2013 Dec 27;56(24):10103-17. doi: 10.1021/jm401543h. Epub 2013 Dec 12. J Med Chem. 2013. PMID: 24274400 Free PMC article.

4

Discovery of a potent and selective α3β4 nicotinic acetylcholine receptor antagonist from an α-conotoxin synthetic combinatorial library.

Chang YP, Banerjee J, Dowell C, Wu J, Gyanda R, Houghten RA, Toll L, McIntosh JM, Armishaw CJ. Chang YP, et al. Among authors: toll l. J Med Chem. 2014 Apr 24;57(8):3511-21. doi: 10.1021/jm500183r. Epub 2014 Apr 3. J Med Chem. 2014. PMID: 24649848 Free PMC article.

5

AT-1001: a high-affinity α3β4 nAChR ligand with novel nicotine-suppressive pharmacology.

Cippitelli A, Wu J, Gaiolini KA, Mercatelli D, Schoch J, Gorman M, Ramirez A, Ciccocioppo R, Khroyan TV, Yasuda D, Zaveri NT, Pascual C, Xie XS, Toll L. Cippitelli A, et al. Among authors: toll l. Br J Pharmacol. 2015 Apr;172(7):1834-45. doi: 10.1111/bph.13034. Epub 2015 Jan 23. Br J Pharmacol. 2015. PMID: 25440006 Free PMC article.

6

A key role for the N/OFQ-NOP receptor system in modulating nicotine taking in a model of nicotine and alcohol co-administration.

Cippitelli A, Schoch J, Debevec G, Brunori G, Zaveri NT, Toll L. Cippitelli A, et al. Among authors: toll l. Sci Rep. 2016 May 20;6:26594. doi: 10.1038/srep26594. Sci Rep. 2016. PMID: 27199205 Free PMC article.

7

Differential regulation of alcohol taking and seeking by antagonism at α4β2 and α3β4 nAChRs.

Cippitelli A, Brunori G, Schoch J, Armishaw CJ, Wu J, Zaveri NT, Giulianotti MA, Welmaker GS, Toll L. Cippitelli A, et al. Among authors: toll l. Psychopharmacology (Berl). 2018 Jun;235(6):1745-1757. doi: 10.1007/s00213-018-4883-y. Epub 2018 Mar 23. Psychopharmacology (Berl). 2018. PMID: 29572652 Free PMC article.

8

Influence of neuropathic pain on nicotinic acetylcholine receptor plasticity and behavioral responses to nicotine in rats.

Brunori G, Schoch J, Mercatelli D, Ozawa A, Toll L, Cippitelli A. Brunori G, et al. Among authors: toll l. Pain. 2018 Nov;159(11):2179-2191. doi: 10.1097/j.pain.0000000000001318. Pain. 2018. PMID: 29939964 Free PMC article.

9

Pharmacological stress is required for the anti-alcohol effect of the α3β4* nAChR partial agonist AT-1001.

Cippitelli A, Brunori G, Gaiolini KA, Zaveri NT, Toll L. Cippitelli A, et al. Among authors: toll l. Neuropharmacology. 2015 Jun;93:229-36. doi: 10.1016/j.neuropharm.2015.02.005. Epub 2015 Feb 14. Neuropharmacology. 2015. PMID: 25689019 Free PMC article.

10

Potent and selective NOP receptor activation reduces cocaine self-administration in rats by lowering hedonic set point.

Cippitelli A, Barnes M, Zaveri NT, Toll L. Cippitelli A, et al. Among authors: toll l. Addict Biol. 2020 Nov;25(6):e12844. doi: 10.1111/adb.12844. Epub 2019 Nov 10. Addict Biol. 2020. PMID: 31709687

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