Welmaker GS - Search Results

1

Highly Selective and Potent α4β2 nAChR Antagonist Inhibits Nicotine Self-Administration and Reinstatement in Rats.

Wu J, Cippitelli A, Zhang Y, Debevec G, Schoch J, Ozawa A, Yu Y, Liu H, Chen W, Houghten RA, Welmaker GS, Giulianotti MA, Toll L. Wu J, et al. Among authors: welmaker gs. J Med Chem. 2017 Dec 28;60(24):10092-10104. doi: 10.1021/acs.jmedchem.7b01250. Epub 2017 Dec 13. J Med Chem. 2017. PMID: 29178785 Free PMC article.

2

Scaffold ranking and positional scanning utilized in the discovery of nAChR-selective compounds suitable for optimization studies.

Wu J, Zhang Y, Maida LE, Santos RG, Welmaker GS, LaVoi TM, Nefzi A, Yu Y, Houghten RA, Toll L, Giulianotti MA. Wu J, et al. Among authors: welmaker gs. J Med Chem. 2013 Dec 27;56(24):10103-17. doi: 10.1021/jm401543h. Epub 2013 Dec 12. J Med Chem. 2013. PMID: 24274400 Free PMC article.

3

Combinatorial Libraries As a Tool for the Discovery of Novel, Broad-Spectrum Antibacterial Agents Targeting the ESKAPE Pathogens.

Fleeman R, LaVoi TM, Santos RG, Morales A, Nefzi A, Welmaker GS, Medina-Franco JL, Giulianotti MA, Houghten RA, Shaw LN. Fleeman R, et al. Among authors: welmaker gs. J Med Chem. 2015 Apr 23;58(8):3340-55. doi: 10.1021/jm501628s. Epub 2015 Apr 1. J Med Chem. 2015. PMID: 25780985 Free PMC article.

4

Differential regulation of alcohol taking and seeking by antagonism at α4β2 and α3β4 nAChRs.

Cippitelli A, Brunori G, Schoch J, Armishaw CJ, Wu J, Zaveri NT, Giulianotti MA, Welmaker GS, Toll L. Cippitelli A, et al. Among authors: welmaker gs. Psychopharmacology (Berl). 2018 Jun;235(6):1745-1757. doi: 10.1007/s00213-018-4883-y. Epub 2018 Mar 23. Psychopharmacology (Berl). 2018. PMID: 29572652 Free PMC article.

5

Direct Phenotypic Screening in Mice: Identification of Individual, Novel Antinociceptive Compounds from a Library of 734,821 Pyrrolidine Bis-piperazines.

Houghten RA, Ganno ML, McLaughlin JP, Dooley CT, Eans SO, Santos RG, LaVoi T, Nefzi A, Welmaker G, Giulianotti MA, Toll L. Houghten RA, et al. ACS Comb Sci. 2016 Jan 11;18(1):51-64. doi: 10.1021/acscombsci.5b00126. Epub 2016 Jan 5. ACS Comb Sci. 2016. PMID: 26651386 Free PMC article.

6

Identification of a Novel Polyamine Scaffold With Potent Efflux Pump Inhibition Activity Toward Multi-Drug Resistant Bacterial Pathogens.

Fleeman RM, Debevec G, Antonen K, Adams JL, Santos RG, Welmaker GS, Houghten RA, Giulianotti MA, Shaw LN. Fleeman RM, et al. Among authors: welmaker gs. Front Microbiol. 2018 Jun 14;9:1301. doi: 10.3389/fmicb.2018.01301. eCollection 2018. Front Microbiol. 2018. PMID: 29963035 Free PMC article.

7

Small-Molecule Inhibitors Targeting Topoisomerase I as Novel Antituberculosis Agents.

Sandhaus S, Annamalai T, Welmaker G, Houghten RA, Paz C, Garcia PK, Andres A, Narula G, Rodrigues Felix C, Geden S, Netherton M, Gupta R, Rohde KH, Giulianotti MA, Tse-Dinh YC. Sandhaus S, et al. Antimicrob Agents Chemother. 2016 Jun 20;60(7):4028-36. doi: 10.1128/AAC.00288-16. Print 2016 Jul. Antimicrob Agents Chemother. 2016. PMID: 27114277 Free PMC article.

8

Shifting from the single to the multitarget paradigm in drug discovery.

Medina-Franco JL, Giulianotti MA, Welmaker GS, Houghten RA. Medina-Franco JL, et al. Among authors: welmaker gs. Drug Discov Today. 2013 May;18(9-10):495-501. doi: 10.1016/j.drudis.2013.01.008. Epub 2013 Jan 20. Drug Discov Today. 2013. PMID: 23340113 Free PMC article. Review.

9

Synthesis and 5-hydroxytryptamine (5-HT) activity of 2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5-(6H)ones and 2,3,4,4a,5,6-hexahydro-1H-pyrazino[1,2-a]quinoxalines.

Welmaker GS, Nelson JA, Sabalski JE, Sabb AL, Potoski JR, Graziano D, Kagan M, Coupet J, Dunlop J, Mazandarani H, Rosenzweig-Lipson S, Sukoff S, Zhang Y. Welmaker GS, et al. Bioorg Med Chem Lett. 2000 Sep 4;10(17):1991-4. doi: 10.1016/s0960-894x(00)00400-5. Bioorg Med Chem Lett. 2000. PMID: 10987434

10

Cycloalkyl[b][1,4]benzodiazepinoindoles are agonists at the human 5-HT2C receptor.

Sabb AL, Vogel RL, Welmaker GS, Sabalski JE, Coupet J, Dunlop J, Rosenzweig-Lipson S, Harrison B. Sabb AL, et al. Among authors: welmaker gs. Bioorg Med Chem Lett. 2004 May 17;14(10):2603-7. doi: 10.1016/j.bmcl.2004.02.100. Bioorg Med Chem Lett. 2004. PMID: 15109661

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