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Engagement of MHC class I by the inhibitory receptor LILRB1 suppresses macrophages and is a target of cancer immunotherapy.
Barkal AA, Weiskopf K, Kao KS, Gordon SR, Rosental B, Yiu YY, George BM, Markovic M, Ring NG, Tsai JM, McKenna KM, Ho PY, Cheng RZ, Chen JY, Barkal LJ, Ring AM, Weissman IL, Maute RL. Barkal AA, et al. Among authors: weissman il. Nat Immunol. 2018 Jan;19(1):76-84. doi: 10.1038/s41590-017-0004-z. Epub 2017 Nov 27. Nat Immunol. 2018. PMID: 29180808 Free PMC article.
Stem cells, cancer, and cancer stem cells.
Reya T, Morrison SJ, Clarke MF, Weissman IL. Reya T, et al. Among authors: weissman il. Nature. 2001 Nov 1;414(6859):105-11. doi: 10.1038/35102167. Nature. 2001. PMID: 11689955 Free article. Review.
Macrophages as mediators of tumor immunosurveillance.
Jaiswal S, Chao MP, Majeti R, Weissman IL. Jaiswal S, et al. Among authors: weissman il. Trends Immunol. 2010 Jun;31(6):212-9. doi: 10.1016/j.it.2010.04.001. Epub 2010 May 7. Trends Immunol. 2010. PMID: 20452821 Free PMC article. Review.
The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors.
Willingham SB, Volkmer JP, Gentles AJ, Sahoo D, Dalerba P, Mitra SS, Wang J, Contreras-Trujillo H, Martin R, Cohen JD, Lovelace P, Scheeren FA, Chao MP, Weiskopf K, Tang C, Volkmer AK, Naik TJ, Storm TA, Mosley AR, Edris B, Schmid SM, Sun CK, Chua MS, Murillo O, Rajendran P, Cha AC, Chin RK, Kim D, Adorno M, Raveh T, Tseng D, Jaiswal S, Enger PØ, Steinberg GK, Li G, So SK, Majeti R, Harsh GR, van de Rijn M, Teng NN, Sunwoo JB, Alizadeh AA, Clarke MF, Weissman IL. Willingham SB, et al. Among authors: weissman il. Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6662-7. doi: 10.1073/pnas.1121623109. Epub 2012 Mar 26. Proc Natl Acad Sci U S A. 2012. PMID: 22451913 Free PMC article.
Antibody therapy targeting the CD47 protein is effective in a model of aggressive metastatic leiomyosarcoma.
Edris B, Weiskopf K, Volkmer AK, Volkmer JP, Willingham SB, Contreras-Trujillo H, Liu J, Majeti R, West RB, Fletcher JA, Beck AH, Weissman IL, van de Rijn M. Edris B, et al. Among authors: weissman il. Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6656-61. doi: 10.1073/pnas.1121629109. Epub 2012 Mar 26. Proc Natl Acad Sci U S A. 2012. PMID: 22451919 Free PMC article.
Flipping the script on macrophages in leiomyosarcoma.
Edris B, Weiskopf K, Weissman IL, van de Rijn M. Edris B, et al. Among authors: weissman il. Oncoimmunology. 2012 Oct 1;1(7):1202-1204. doi: 10.4161/onci.20799. Oncoimmunology. 2012. PMID: 23170280 Free PMC article.
900 results