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Page 1
CD4+ and B Lymphocyte Expression Quantitative Traits at Rheumatoid Arthritis Risk Loci in Patients With Untreated Early Arthritis: Implications for Causal Gene Identification.
Thalayasingam N, Nair N, Skelton AJ, Massey J, Anderson AE, Clark AD, Diboll J, Lendrem DW, Reynard LN, Cordell HJ, Eyre S, Isaacs JD, Barton A, Pratt AG. Thalayasingam N, et al. Arthritis Rheumatol. 2018 Mar;70(3):361-370. doi: 10.1002/art.40393. Epub 2018 Jan 30. Arthritis Rheumatol. 2018. PMID: 29193869 Free PMC article.
Capture Hi-C identifies a novel causal gene, IL20RA, in the pan-autoimmune genetic susceptibility region 6q23.
McGovern A, Schoenfelder S, Martin P, Massey J, Duffus K, Plant D, Yarwood A, Pratt AG, Anderson AE, Isaacs JD, Diboll J, Thalayasingam N, Ospelt C, Barton A, Worthington J, Fraser P, Eyre S, Orozco G. McGovern A, et al. Among authors: thalayasingam n. Genome Biol. 2016 Nov 1;17(1):212. doi: 10.1186/s13059-016-1078-x. Genome Biol. 2016. PMID: 27799070 Free PMC article.
Lymphocyte DNA methylation mediates genetic risk at shared immune-mediated disease loci.
Clark AD, Nair N, Anderson AE, Thalayasingam N, Naamane N, Skelton AJ, Diboll J, Barton A, Eyre S, Isaacs JD, Pratt AG, Reynard LN. Clark AD, et al. Among authors: thalayasingam n. J Allergy Clin Immunol. 2020 May;145(5):1438-1451. doi: 10.1016/j.jaci.2019.12.910. Epub 2020 Jan 13. J Allergy Clin Immunol. 2020. PMID: 31945409 Free PMC article.
Interferon-α-mediated therapeutic resistance in early rheumatoid arthritis implicates epigenetic reprogramming.
Cooles FAH, Tarn J, Lendrem DW, Naamane N, Lin CM, Millar B, Maney NJ, Anderson AE, Thalayasingam N, Diboll J, Bondet V, Duffy D, Barnes MR, Smith GR, Ng S, Watson D, Henkin R, Cope AP, Reynard LN, Pratt AG; RA-MAP Consortium; Isaacs JD. Cooles FAH, et al. Among authors: thalayasingam n. Ann Rheum Dis. 2022 Aug 11;81(9):1214-1223. doi: 10.1136/annrheumdis-2022-222370. Ann Rheum Dis. 2022. PMID: 35680389 Free PMC article.
Anti-TNF therapy.
Thalayasingam N, Isaacs JD. Thalayasingam N, et al. Best Pract Res Clin Rheumatol. 2011 Aug;25(4):549-67. doi: 10.1016/j.berh.2011.10.004. Best Pract Res Clin Rheumatol. 2011. PMID: 22137924 Review.
New developments in Sjogren's syndrome.
Thalayasingam N, Baldwin K, Judd C, Ng WF. Thalayasingam N, et al. Rheumatology (Oxford). 2021 Dec 24;60(Suppl 6):vi53-vi61. doi: 10.1093/rheumatology/keab466. Rheumatology (Oxford). 2021. PMID: 34951923 Free PMC article. Review.
Sjögren's syndrome: shedding light on emerging and key drug targets.
Ridgewell D, Thalayasingam N, Ng WF. Ridgewell D, et al. Among authors: thalayasingam n. Expert Opin Ther Targets. 2022 Oct;26(10):869-882. doi: 10.1080/14728222.2022.2157259. Epub 2022 Dec 28. Expert Opin Ther Targets. 2022. PMID: 36576336 Review.