Abdel-Rahman HM - Search Results

1

Novel 1,2,4-triazole derivatives as potential anticancer agents: Design, synthesis, molecular docking and mechanistic studies.

El-Sherief HAM, Youssif BGM, Bukhari SNA, Abdel-Aziz M, Abdel-Rahman HM. El-Sherief HAM, et al. Bioorg Chem. 2018 Feb;76:314-325. doi: 10.1016/j.bioorg.2017.12.013. Epub 2017 Dec 5. Bioorg Chem. 2018. PMID: 29227915

2

Novel 5-(2-hydroxyphenyl)-3-substituted-2,3-dihydro-1,3,4-oxadiazole-2-thione derivatives: promising anticancer agents.

Aboraia AS, Abdel-Rahman HM, Mahfouz NM, El-Gendy MA. Aboraia AS, et al. Bioorg Med Chem. 2006 Feb 15;14(4):1236-46. doi: 10.1016/j.bmc.2005.09.053. Epub 2005 Oct 18. Bioorg Med Chem. 2006. PMID: 16242340

3

Design and synthesis of potent beta-secretase (BACE1) inhibitors with P1' carboxylic acid bioisosteres.

Kimura T, Hamada Y, Stochaj M, Ikari H, Nagamine A, Abdel-Rahman H, Igawa N, Hidaka K, Nguyen JT, Saito K, Hayashi Y, Kiso Y. Kimura T, et al. Bioorg Med Chem Lett. 2006 May 1;16(9):2380-6. doi: 10.1016/j.bmcl.2006.01.108. Epub 2006 Feb 14. Bioorg Med Chem Lett. 2006. PMID: 16481167

4

BACE1 inhibitors: optimization by replacing the P1' residue with non-acidic moiety.

Hamada Y, Abdel-Rahman H, Yamani A, Nguyen JT, Stochaj M, Hidaka K, Kimura T, Hayashi Y, Saito K, Ishiura S, Kiso Y. Hamada Y, et al. Bioorg Med Chem Lett. 2008 Mar 1;18(5):1649-53. doi: 10.1016/j.bmcl.2008.01.058. Epub 2008 Jan 19. Bioorg Med Chem Lett. 2008. PMID: 18249539

5

Design, synthesis and molecular modeling study of acylated 1,2,4-triazole-3-acetates with potential anti-inflammatory activity.

Abdel-Megeed AM, Abdel-Rahman HM, Alkaramany GE, El-Gendy MA. Abdel-Megeed AM, et al. Eur J Med Chem. 2009 Jan;44(1):117-23. doi: 10.1016/j.ejmech.2008.03.017. Epub 2008 Apr 1. Eur J Med Chem. 2009. PMID: 18455273

6

Design of pentapeptidic BACE1 inhibitors with carboxylic acid bioisosteres at P1' and P4 positions.

Tagad HD, Hamada Y, Nguyen JT, Hamada T, Abdel-Rahman H, Yamani A, Nagamine A, Ikari H, Igawa N, Hidaka K, Sohma Y, Kimura T, Kiso Y. Tagad HD, et al. Bioorg Med Chem. 2010 May 1;18(9):3175-86. doi: 10.1016/j.bmc.2010.03.032. Epub 2010 Mar 21. Bioorg Med Chem. 2010. PMID: 20381362

7

Synthesis and anti-mycobacterial evaluation of some pyrazine-2-carboxylic acid hydrazide derivatives.

Abdel-Aziz M, Abdel-Rahman HM. Abdel-Aziz M, et al. Eur J Med Chem. 2010 Aug;45(8):3384-8. doi: 10.1016/j.ejmech.2010.04.025. Epub 2010 Apr 28. Eur J Med Chem. 2010. PMID: 20488590

8

Trimethyl-4-oxo-4,5,6,7-tetrahydroindazole-1-acetic acid: a new lead compound with selective COX-2 inhibitory activity.

Abdel-Rahman HM, Ozadali K. Abdel-Rahman HM, et al. Arch Pharm (Weinheim). 2012 Nov;345(11):878-83. doi: 10.1002/ardp.201200193. Epub 2012 Aug 21. Arch Pharm (Weinheim). 2012. PMID: 22907715

9

Novel quinazolin-4(3H)-one/Schiff base hybrids as antiproliferative and phosphodiesterase 4 inhibitors: design, synthesis, and docking studies.

Abdel-Rahman HM, Abdel-Aziz M, Canzoneri JC, Gary BD, Piazza GA. Abdel-Rahman HM, et al. Arch Pharm (Weinheim). 2014 Sep;347(9):650-7. doi: 10.1002/ardp.201400083. Epub 2014 Jul 1. Arch Pharm (Weinheim). 2014. PMID: 24985336

10

Synthesis and evaluation of quinazoline amino acid derivatives as mono amine oxidase (MAO) inhibitors.

Khattab SN, Haiba NS, Asal AM, Bekhit AA, Amer A, Abdel-Rahman HM, El-Faham A. Khattab SN, et al. Bioorg Med Chem. 2015 Jul 1;23(13):3574-85. doi: 10.1016/j.bmc.2015.04.021. Epub 2015 Apr 16. Bioorg Med Chem. 2015. PMID: 25922182

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