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Human Neural Stem Cell Transplantation Rescues Functional Deficits in R6/2 and Q140 Huntington's Disease Mice.
Reidling JC, Relaño-Ginés A, Holley SM, Ochaba J, Moore C, Fury B, Lau A, Tran AH, Yeung S, Salamati D, Zhu C, Hatami A, Cepeda C, Barry JA, Kamdjou T, King A, Coleal-Bergum D, Franich NR, LaFerla FM, Steffan JS, Blurton-Jones M, Meshul CK, Bauer G, Levine MS, Chesselet MF, Thompson LM. Reidling JC, et al. Among authors: laferla fm. Stem Cell Reports. 2018 Jan 9;10(1):58-72. doi: 10.1016/j.stemcr.2017.11.005. Epub 2017 Dec 7. Stem Cell Reports. 2018. PMID: 29233555 Free PMC article.
Pathways by which Abeta facilitates tau pathology.
Blurton-Jones M, Laferla FM. Blurton-Jones M, et al. Among authors: laferla fm. Curr Alzheimer Res. 2006 Dec;3(5):437-48. doi: 10.2174/156720506779025242. Curr Alzheimer Res. 2006. PMID: 17168643 Review.
Abeta inhibits the proteasome and enhances amyloid and tau accumulation.
Tseng BP, Green KN, Chan JL, Blurton-Jones M, LaFerla FM. Tseng BP, et al. Among authors: laferla fm. Neurobiol Aging. 2008 Nov;29(11):1607-18. doi: 10.1016/j.neurobiolaging.2007.04.014. Epub 2007 Jun 1. Neurobiol Aging. 2008. PMID: 17544172 Free PMC article.
Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease.
Blurton-Jones M, Kitazawa M, Martinez-Coria H, Castello NA, Müller FJ, Loring JF, Yamasaki TR, Poon WW, Green KN, LaFerla FM. Blurton-Jones M, et al. Among authors: laferla fm. Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13594-9. doi: 10.1073/pnas.0901402106. Epub 2009 Jul 24. Proc Natl Acad Sci U S A. 2009. PMID: 19633196 Free PMC article.
IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome.
Thompson LM, Aiken CT, Kaltenbach LS, Agrawal N, Illes K, Khoshnan A, Martinez-Vincente M, Arrasate M, O'Rourke JG, Khashwji H, Lukacsovich T, Zhu YZ, Lau AL, Massey A, Hayden MR, Zeitlin SO, Finkbeiner S, Green KN, LaFerla FM, Bates G, Huang L, Patterson PH, Lo DC, Cuervo AM, Marsh JL, Steffan JS. Thompson LM, et al. Among authors: laferla fm. J Cell Biol. 2009 Dec 28;187(7):1083-99. doi: 10.1083/jcb.200909067. Epub 2009 Dec 21. J Cell Biol. 2009. PMID: 20026656 Free PMC article.
277 results