Kossiakoff AA - Search Results

1

Locking the Elbow: Improved Antibody Fab Fragments as Chaperones for Structure Determination.

Bailey LJ, Sheehy KM, Dominik PK, Liang WG, Rui H, Clark M, Jaskolowski M, Kim Y, Deneka D, Tang WJ, Kossiakoff AA. Bailey LJ, et al. Among authors: kossiakoff aa. J Mol Biol. 2018 Feb 2;430(3):337-347. doi: 10.1016/j.jmb.2017.12.012. Epub 2017 Dec 19. J Mol Biol. 2018. PMID: 29273204 Free PMC article.

2

Biosynthetic phage display: a novel protein engineering tool combining chemical and genetic diversity.

Dwyer MA, Lu W, Dwyer JJ, Kossiakoff AA. Dwyer MA, et al. Among authors: kossiakoff aa. Chem Biol. 2000 Apr;7(4):263-74. doi: 10.1016/s1074-5521(00)00102-2. Chem Biol. 2000. PMID: 10780926

3

The functional binding epitope of a high affinity variant of human growth hormone mapped by shotgun alanine-scanning mutagenesis: insights into the mechanisms responsible for improved affinity.

Pal G, Kossiakoff AA, Sidhu SS. Pal G, et al. Among authors: kossiakoff aa. J Mol Biol. 2003 Sep 5;332(1):195-204. doi: 10.1016/s0022-2836(03)00898-2. J Mol Biol. 2003. PMID: 12946357

4

Intramolecular cooperativity in a protein binding site assessed by combinatorial shotgun scanning mutagenesis.

Pál G, Ultsch MH, Clark KP, Currell B, Kossiakoff AA, Sidhu SS. Pál G, et al. Among authors: kossiakoff aa. J Mol Biol. 2005 Apr 1;347(3):489-94. doi: 10.1016/j.jmb.2005.01.040. J Mol Biol. 2005. PMID: 15755445

5

Exploring the capacity of minimalist protein interfaces: interface energetics and affinity maturation to picomolar KD of a single-domain antibody with a flat paratope.

Koide A, Tereshko V, Uysal S, Margalef K, Kossiakoff AA, Koide S. Koide A, et al. Among authors: kossiakoff aa. J Mol Biol. 2007 Nov 2;373(4):941-53. doi: 10.1016/j.jmb.2007.08.027. Epub 2007 Aug 21. J Mol Biol. 2007. PMID: 17888451 Free PMC article.

6

Understanding mechanisms governing protein-protein interactions from synthetic binding interfaces.

Kossiakoff AA, Koide S. Kossiakoff AA, et al. Curr Opin Struct Biol. 2008 Aug;18(4):499-506. doi: 10.1016/j.sbi.2008.06.004. Epub 2008 Aug 4. Curr Opin Struct Biol. 2008. PMID: 18638552 Review.

7

Crystal structure of full-length KcsA in its closed conformation.

Uysal S, Vásquez V, Tereshko V, Esaki K, Fellouse FA, Sidhu SS, Koide S, Perozo E, Kossiakoff A. Uysal S, et al. Proc Natl Acad Sci U S A. 2009 Apr 21;106(16):6644-9. doi: 10.1073/pnas.0810663106. Epub 2009 Apr 3. Proc Natl Acad Sci U S A. 2009. PMID: 19346472 Free PMC article.

8

A portable RNA sequence whose recognition by a synthetic antibody facilitates structural determination.

Koldobskaya Y, Duguid EM, Shechner DM, Suslov NB, Ye J, Sidhu SS, Bartel DP, Koide S, Kossiakoff AA, Piccirilli JA. Koldobskaya Y, et al. Among authors: kossiakoff aa. Nat Struct Mol Biol. 2011 Jan;18(1):100-6. doi: 10.1038/nsmb.1945. Epub 2010 Dec 12. Nat Struct Mol Biol. 2011. PMID: 21151117 Free PMC article.

9

Allosteric control of ligand-binding affinity using engineered conformation-specific effector proteins.

Rizk SS, Paduch M, Heithaus JH, Duguid EM, Sandstrom A, Kossiakoff AA. Rizk SS, et al. Among authors: kossiakoff aa. Nat Struct Mol Biol. 2011 Apr;18(4):437-42. doi: 10.1038/nsmb.2002. Epub 2011 Mar 6. Nat Struct Mol Biol. 2011. PMID: 21378967 Free PMC article.

10

Applications for an engineered Protein-G variant with a pH controllable affinity to antibody fragments.

Bailey LJ, Sheehy KM, Hoey RJ, Schaefer ZP, Ura M, Kossiakoff AA. Bailey LJ, et al. Among authors: kossiakoff aa. J Immunol Methods. 2014 Dec 15;415:24-30. doi: 10.1016/j.jim.2014.10.003. Epub 2014 Oct 22. J Immunol Methods. 2014. PMID: 25450256 Free PMC article.

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