Nes WD - Search Results

1

CYP51 is an essential drug target for the treatment of primary amoebic meningoencephalitis (PAM).

Debnath A, Calvet CM, Jennings G, Zhou W, Aksenov A, Luth MR, Abagyan R, Nes WD, McKerrow JH, Podust LM. Debnath A, et al. Among authors: nes wd. PLoS Negl Trop Dis. 2017 Dec 28;11(12):e0006104. doi: 10.1371/journal.pntd.0006104. eCollection 2017 Dec. PLoS Negl Trop Dis. 2017. PMID: 29284029 Free PMC article.

2

Enzymatic chokepoints and synergistic drug targets in the sterol biosynthesis pathway of Naegleria fowleri.

Zhou W, Debnath A, Jennings G, Hahn HJ, Vanderloop BH, Chaudhuri M, Nes WD, Podust LM. Zhou W, et al. Among authors: nes wd. PLoS Pathog. 2018 Sep 13;14(9):e1007245. doi: 10.1371/journal.ppat.1007245. eCollection 2018 Sep. PLoS Pathog. 2018. PMID: 30212566 Free PMC article.

3

Sterol methyltransferase2: purification, properties, and inhibition.

Zhou W, Nes WD. Zhou W, et al. Among authors: nes wd. Arch Biochem Biophys. 2003 Dec 1;420(1):18-34. doi: 10.1016/j.abb.2003.08.029. Arch Biochem Biophys. 2003. PMID: 14622971

4

Cholesterol import fails to prevent catalyst-based inhibition of ergosterol synthesis and cell proliferation of Trypanosoma brucei.

Zhou W, Cross GA, Nes WD. Zhou W, et al. Among authors: nes wd. J Lipid Res. 2007 Mar;48(3):665-73. doi: 10.1194/jlr.M600404-JLR200. Epub 2006 Nov 26. J Lipid Res. 2007. PMID: 17127773 Free article.

5

Substrate-based inhibitors of the (S)-adenosyl-L-methionine:delta24(25)- to delta24(28)-sterol methyl transferase from Saccharomyces cerevisiae.

Nes WD, Guo D, Zhou W. Nes WD, et al. Arch Biochem Biophys. 1997 Jun 1;342(1):68-81. doi: 10.1006/abbi.1997.9984. Arch Biochem Biophys. 1997. PMID: 9185615

6

Disruption of ergosterol biosynthesis, growth, and the morphological transition in Candida albicans by sterol methyltransferase inhibitors containing sulfur at C-25 in the sterol side chain.

Kanagasabai R, Zhou W, Liu J, Nguyen TT, Veeramachaneni P, Nes WD. Kanagasabai R, et al. Among authors: nes wd. Lipids. 2004 Aug;39(8):737-46. doi: 10.1007/s11745-004-1290-7. Lipids. 2004. PMID: 15638241

7

Mechanism-based active site modification of the soybean sterol methyltransferase by 26,27-dehydrocycloartenol.

Song Z, Zhou W, Liu J, Nes WD. Song Z, et al. Among authors: nes wd. Bioorg Med Chem Lett. 2004 Jan 5;14(1):33-6. doi: 10.1016/j.bmcl.2003.10.015. Bioorg Med Chem Lett. 2004. PMID: 14684292

8

Mechanistic analysis of a multiple product sterol methyltransferase implicated in ergosterol biosynthesis in Trypanosoma brucei.

Zhou W, Lepesheva GI, Waterman MR, Nes WD. Zhou W, et al. Among authors: nes wd. J Biol Chem. 2006 Mar 10;281(10):6290-6. doi: 10.1074/jbc.M511749200. Epub 2006 Jan 12. J Biol Chem. 2006. PMID: 16414960 Free article.

9

CYP51 from Trypanosoma brucei is obtusifoliol-specific.

Lepesheva GI, Nes WD, Zhou W, Hill GC, Waterman MR. Lepesheva GI, et al. Among authors: nes wd. Biochemistry. 2004 Aug 24;43(33):10789-99. doi: 10.1021/bi048967t. Biochemistry. 2004. PMID: 15311940

10

Antifungal sterol biosynthesis inhibitors.

Guo DA, Mangla AT, Zhou W, Lopez M, Jia Z, Nichols SD, Nes WD. Guo DA, et al. Among authors: nes wd. Subcell Biochem. 1997;28:89-116. doi: 10.1007/978-1-4615-5901-6_4. Subcell Biochem. 1997. PMID: 9090292 Review.

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