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Polyphosphate/platelet factor 4 complexes can mediate heparin-independent platelet activation in heparin-induced thrombocytopenia.
Cines DB, Yarovoi SV, Zaitsev SV, Lebedeva T, Rauova L, Poncz M, Arepally GM, Khandelwal S, Stepanova V, Rux AH, Cuker A, Guo C, Ocariza LM, Travers RJ, Smith SA, Kim H, Morrissey JH, Conway EM. Cines DB, et al. Among authors: ocariza lm. Blood Adv. 2016 Nov 22;1(1):62-74. doi: 10.1182/bloodadvances.2016000877. eCollection 2016 Nov 29. Blood Adv. 2016. PMID: 29296696 Free PMC article.
Polyphosphate suppresses complement via the terminal pathway.
Wat JM, Foley JH, Krisinger MJ, Ocariza LM, Lei V, Wasney GA, Lameignere E, Strynadka NC, Smith SA, Morrissey JH, Conway EM. Wat JM, et al. Among authors: ocariza lm. Blood. 2014 Jan 30;123(5):768-76. doi: 10.1182/blood-2013-07-515726. Epub 2013 Dec 13. Blood. 2014. PMID: 24335501 Free PMC article.