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Page 1
X-ray crystal structure of plasmin with tranexamic acid-derived active site inhibitors.
Law RHP, Wu G, Leung EWW, Hidaka K, Quek AJ, Caradoc-Davies TT, Jeevarajah D, Conroy PJ, Kirby NM, Norton RS, Tsuda Y, Whisstock JC. Law RHP, et al. Among authors: quek aj. Blood Adv. 2017 May 9;1(12):766-771. doi: 10.1182/bloodadvances.2016004150. eCollection 2017 May 9. Blood Adv. 2017. PMID: 29296720 Free PMC article.
The X-ray crystal structure of full-length human plasminogen.
Law RH, Caradoc-Davies T, Cowieson N, Horvath AJ, Quek AJ, Encarnacao JA, Steer D, Cowan A, Zhang Q, Lu BG, Pike RN, Smith AI, Coughlin PB, Whisstock JC. Law RH, et al. Among authors: quek aj. Cell Rep. 2012 Mar 29;1(3):185-90. doi: 10.1016/j.celrep.2012.02.012. Epub 2012 Mar 8. Cell Rep. 2012. PMID: 22832192 Free article.
Dimerization is not a determining factor for functional high affinity human plasminogen binding by the group A streptococcal virulence factor PAM and is mediated by specific residues within the PAM a1a2 domain.
Bhattacharya S, Liang Z, Quek AJ, Ploplis VA, Law R, Castellino FJ. Bhattacharya S, et al. Among authors: quek aj. J Biol Chem. 2014 Aug 1;289(31):21684-93. doi: 10.1074/jbc.M114.570218. Epub 2014 Jun 24. J Biol Chem. 2014. PMID: 24962580 Free PMC article.
Tranexamic acid is an active site inhibitor of urokinase plasminogen activator.
Wu G, Mazzitelli BA, Quek AJ, Veldman MJ, Conroy PJ, Caradoc-Davies TT, Ooms LM, Tuck KL, Schoenecker JG, Whisstock JC, Law RHP. Wu G, et al. Among authors: quek aj. Blood Adv. 2019 Mar 12;3(5):729-733. doi: 10.1182/bloodadvances.2018025429. Blood Adv. 2019. PMID: 30814058 Free PMC article.
Structural studies of plasmin inhibition.
Wu G, Quek AJ, Caradoc-Davies TT, Ekkel SM, Mazzitelli B, Whisstock JC, Law RHP. Wu G, et al. Among authors: quek aj. Biochem Soc Trans. 2019 Apr 30;47(2):541-557. doi: 10.1042/BST20180211. Epub 2019 Mar 5. Biochem Soc Trans. 2019. PMID: 30837322 Review.
Structure and Function Characterization of the a1a2 Motifs of Streptococcus pyogenes M Protein in Human Plasminogen Binding.
Quek AJH, Mazzitelli BA, Wu G, Leung EWW, Caradoc-Davies TT, Lloyd GJ, Jeevarajah D, Conroy PJ, Sanderson-Smith M, Yuan Y, Ayinuola YA, Castellino FJ, Whisstock JC, Law RHP. Quek AJH, et al. J Mol Biol. 2019 Sep 6;431(19):3804-3813. doi: 10.1016/j.jmb.2019.07.003. Epub 2019 Jul 8. J Mol Biol. 2019. PMID: 31295457 Free PMC article.
Human Plasminogen Exacerbates Clostridioides difficile Enteric Disease and Alters the Spore Surface.
Awad MM, Hutton ML, Quek AJ, Klare WP, Mileto SJ, Mackin K, Ly D, Oorschot V, Bosnjak M, Jenkin G, Conroy PJ, West N, Fulcher A, Costin A, Day CJ, Jennings MP, Medcalf RL, Sanderson-Smith M, Cordwell SJ, Law RHP, Whisstock JC, Lyras D. Awad MM, et al. Among authors: quek aj. Gastroenterology. 2020 Oct;159(4):1431-1443.e6. doi: 10.1053/j.gastro.2020.06.032. Epub 2020 Jun 20. Gastroenterology. 2020. PMID: 32574621
15 results