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A zebrafish model for C9orf72 ALS reveals RNA toxicity as a pathogenic mechanism.
Swinnen B, Bento-Abreu A, Gendron TF, Boeynaems S, Bogaert E, Nuyts R, Timmers M, Scheveneels W, Hersmus N, Wang J, Mizielinska S, Isaacs AM, Petrucelli L, Lemmens R, Van Damme P, Van Den Bosch L, Robberecht W. Swinnen B, et al. Among authors: petrucelli l. Acta Neuropathol. 2018 Mar;135(3):427-443. doi: 10.1007/s00401-017-1796-5. Epub 2018 Jan 4. Acta Neuropathol. 2018. PMID: 29302778
The role of tau in neurodegeneration.
Gendron TF, Petrucelli L. Gendron TF, et al. Among authors: petrucelli l. Mol Neurodegener. 2009 Mar 11;4:13. doi: 10.1186/1750-1326-4-13. Mol Neurodegener. 2009. PMID: 19284597 Free PMC article.
Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity.
Zhang YJ, Xu YF, Cook C, Gendron TF, Roettges P, Link CD, Lin WL, Tong J, Castanedes-Casey M, Ash P, Gass J, Rangachari V, Buratti E, Baralle F, Golde TE, Dickson DW, Petrucelli L. Zhang YJ, et al. Among authors: petrucelli l. Proc Natl Acad Sci U S A. 2009 May 5;106(18):7607-12. doi: 10.1073/pnas.0900688106. Epub 2009 Apr 21. Proc Natl Acad Sci U S A. 2009. PMID: 19383787 Free PMC article.
Wild-type human TDP-43 expression causes TDP-43 phosphorylation, mitochondrial aggregation, motor deficits, and early mortality in transgenic mice.
Xu YF, Gendron TF, Zhang YJ, Lin WL, D'Alton S, Sheng H, Casey MC, Tong J, Knight J, Yu X, Rademakers R, Boylan K, Hutton M, McGowan E, Dickson DW, Lewis J, Petrucelli L. Xu YF, et al. Among authors: petrucelli l. J Neurosci. 2010 Aug 11;30(32):10851-9. doi: 10.1523/JNEUROSCI.1630-10.2010. J Neurosci. 2010. PMID: 20702714 Free PMC article.
Neuronal sensitivity to TDP-43 overexpression is dependent on timing of induction.
Cannon A, Yang B, Knight J, Farnham IM, Zhang Y, Wuertzer CA, D'Alton S, Lin WL, Castanedes-Casey M, Rousseau L, Scott B, Jurasic M, Howard J, Yu X, Bailey R, Sarkisian MR, Dickson DW, Petrucelli L, Lewis J. Cannon A, et al. Among authors: petrucelli l. Acta Neuropathol. 2012 Jun;123(6):807-23. doi: 10.1007/s00401-012-0979-3. Epub 2012 Apr 27. Acta Neuropathol. 2012. PMID: 22539017 Free PMC article.
337 results