Verma RK - Search Results

1

The structural determinants of the bitopic binding mode of a negative allosteric modulator of the dopamine D₂ receptor.

Draper-Joyce CJ, Michino M, Verma RK, Klein Herenbrink C, Shonberg J, Kopinathan A, Scammells PJ, Capuano B, Thal DM, Javitch JA, Christopoulos A, Shi L, Lane JR. Draper-Joyce CJ, et al. Among authors: verma rk. Biochem Pharmacol. 2018 Feb;148:315-328. doi: 10.1016/j.bcp.2018.01.002. Epub 2018 Jan 9. Biochem Pharmacol. 2018. PMID: 29325769 Free PMC article.

2

The E2.65A mutation disrupts dynamic binding poses of SB269652 at the dopamine D2 and D3 receptors.

Verma RK, Abramyan AM, Michino M, Free RB, Sibley DR, Javitch JA, Lane JR, Shi L. Verma RK, et al. PLoS Comput Biol. 2018 Jan 16;14(1):e1005948. doi: 10.1371/journal.pcbi.1005948. eCollection 2018 Jan. PLoS Comput Biol. 2018. PMID: 29337986 Free PMC article.

3

The action of a negative allosteric modulator at the dopamine D₂ receptor is dependent upon sodium ions.

Draper-Joyce CJ, Verma RK, Michino M, Shonberg J, Kopinathan A, Klein Herenbrink C, Scammells PJ, Capuano B, Abramyan AM, Thal DM, Javitch JA, Christopoulos A, Shi L, Lane JR. Draper-Joyce CJ, et al. Among authors: verma rk. Sci Rep. 2018 Jan 19;8(1):1208. doi: 10.1038/s41598-018-19642-1. Sci Rep. 2018. PMID: 29352161 Free PMC article.

4

Distinct inactive conformations of the dopamine D2 and D3 receptors correspond to different extents of inverse agonism.

Lane JR, Abramyan AM, Adhikari P, Keen AC, Lee KH, Sanchez J, Verma RK, Lim HD, Yano H, Javitch JA, Shi L. Lane JR, et al. Among authors: verma rk. Elife. 2020 Jan 27;9:e52189. doi: 10.7554/eLife.52189. Elife. 2020. PMID: 31985399 Free PMC article.

5

Evidence for a Stereoselective Mechanism for Bitopic Activity by Extended-Length Antagonists of the D₃ Dopamine Receptor.

Moritz AE, Bonifazi A, Guerrero AM, Kumar V, Free RB, Lane JR, Verma RK, Shi L, Newman AH, Sibley DR. Moritz AE, et al. Among authors: verma rk. ACS Chem Neurosci. 2020 Oct 21;11(20):3309-3320. doi: 10.1021/acschemneuro.0c00425. Epub 2020 Oct 5. ACS Chem Neurosci. 2020. PMID: 32969645 Free PMC article.

6

Molecular Determinants of the Intrinsic Efficacy of the Antipsychotic Aripiprazole.

Klein Herenbrink C, Verma R, Lim HD, Kopinathan A, Keen A, Shonberg J, Draper-Joyce CJ, Scammells PJ, Christopoulos A, Javitch JA, Capuano B, Shi L, Lane JR. Klein Herenbrink C, et al. ACS Chem Biol. 2019 Aug 16;14(8):1780-1792. doi: 10.1021/acschembio.9b00342. Epub 2019 Aug 5. ACS Chem Biol. 2019. PMID: 31339684 Free PMC article.

7

Gs- versus Golf-dependent functional selectivity mediated by the dopamine D₁ receptor.

Yano H, Cai NS, Xu M, Verma RK, Rea W, Hoffman AF, Shi L, Javitch JA, Bonci A, Ferré S. Yano H, et al. Among authors: verma rk. Nat Commun. 2018 Feb 5;9(1):486. doi: 10.1038/s41467-017-02606-w. Nat Commun. 2018. PMID: 29402888 Free PMC article.

8

Toward Understanding the Structural Basis of Partial Agonism at the Dopamine D₃ Receptor.

Michino M, Boateng CA, Donthamsetti P, Yano H, Bakare OM, Bonifazi A, Ellenberger MP, Keck TM, Kumar V, Zhu C, Verma R, Deschamps JR, Javitch JA, Newman AH, Shi L. Michino M, et al. J Med Chem. 2017 Jan 26;60(2):580-593. doi: 10.1021/acs.jmedchem.6b01148. Epub 2017 Jan 5. J Med Chem. 2017. PMID: 27983845 Free PMC article.

9

A structural basis for how ligand binding site changes can allosterically regulate GPCR signaling and engender functional selectivity.

Sanchez-Soto M, Verma RK, Willette BKA, Gonye EC, Moore AM, Moritz AE, Boateng CA, Yano H, Free RB, Shi L, Sibley DR. Sanchez-Soto M, et al. Among authors: verma rk. Sci Signal. 2020 Feb 4;13(617):eaaw5885. doi: 10.1126/scisignal.aaw5885. Sci Signal. 2020. PMID: 32019899 Free PMC article.

10

Computational Modeling of C-Terminal Tails to Predict the Calcium-Dependent Secretion of Endoplasmic Reticulum Resident Proteins.

Trychta KA, Xie B, Verma RK, Xu M, Shi L, Harvey BK. Trychta KA, et al. Among authors: verma rk. Front Chem. 2021 Jun 29;9:689608. doi: 10.3389/fchem.2021.689608. eCollection 2021. Front Chem. 2021. PMID: 34268295 Free PMC article.

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