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Single cell analysis of Crohn's disease patient-derived small intestinal organoids reveals disease activity-dependent modification of stem cell properties.
Suzuki K, Murano T, Shimizu H, Ito G, Nakata T, Fujii S, Ishibashi F, Kawamoto A, Anzai S, Kuno R, Kuwabara K, Takahashi J, Hama M, Nagata S, Hiraguri Y, Takenaka K, Yui S, Tsuchiya K, Nakamura T, Ohtsuka K, Watanabe M, Okamoto R. Suzuki K, et al. Among authors: watanabe m. J Gastroenterol. 2018 Sep;53(9):1035-1047. doi: 10.1007/s00535-018-1437-3. Epub 2018 Jan 27. J Gastroenterol. 2018. PMID: 29374777 Free PMC article.
Interleukin-18 overproduction exacerbates the development of colitis with markedly infiltrated macrophages in interleukin-18 transgenic mice.
Ishikura T, Kanai T, Uraushihara K, Iiyama R, Makita S, Totsuka T, Yamazaki M, Sawada T, Nakamura T, Miyata T, Kitahora T, Hibi T, Hoshino T, Watanabe M. Ishikura T, et al. Among authors: watanabe m. J Gastroenterol Hepatol. 2003 Aug;18(8):960-9. doi: 10.1046/j.1440-1746.2003.03097.x. J Gastroenterol Hepatol. 2003. PMID: 12859727
Macrophage-derived IL-18 targeting for the treatment of Crohn's disease.
Kanai T, Uraushihara K, Totsuka T, Okazawa A, Hibi T, Oshima S, Miyata T, Nakamura T, Watanabe M. Kanai T, et al. Among authors: watanabe m. Curr Drug Targets Inflamm Allergy. 2003 Jun;2(2):131-6. doi: 10.2174/1568010033484250. Curr Drug Targets Inflamm Allergy. 2003. PMID: 14561165 Review.
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