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Blocking PPARγ interaction facilitates Nur77 interdiction of fatty acid uptake and suppresses breast cancer progression.
Yang PB, Hou PP, Liu FY, Hong WB, Chen HZ, Sun XY, Li P, Zhang Y, Ju CY, Luo LJ, Wu SF, Zhou JX, Wang ZJ, He JP, Li L, Zhao TJ, Deng X, Lin T, Wu Q. Yang PB, et al. Among authors: he jp. Proc Natl Acad Sci U S A. 2020 Nov 3;117(44):27412-27422. doi: 10.1073/pnas.2002997117. Epub 2020 Oct 21. Proc Natl Acad Sci U S A. 2020. PMID: 33087562 Free PMC article.
The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK.
Zhan YY, Chen Y, Zhang Q, Zhuang JJ, Tian M, Chen HZ, Zhang LR, Zhang HK, He JP, Wang WJ, Wu R, Wang Y, Shi C, Yang K, Li AZ, Xin YZ, Li TY, Yang JY, Zheng ZH, Yu CD, Lin SC, Chang C, Huang PQ, Lin T, Wu Q. Zhan YY, et al. Among authors: he jp. Nat Chem Biol. 2012 Nov;8(11):897-904. doi: 10.1038/nchembio.1069. Epub 2012 Sep 16. Nat Chem Biol. 2012. PMID: 22983157
Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation.
Li L, Liu Y, Chen HZ, Li FW, Wu JF, Zhang HK, He JP, Xing YZ, Chen Y, Wang WJ, Tian XY, Li AZ, Zhang Q, Huang PQ, Han J, Lin T, Wu Q. Li L, et al. Among authors: he jp. Nat Chem Biol. 2015 May;11(5):339-46. doi: 10.1038/nchembio.1788. Epub 2015 Mar 30. Nat Chem Biol. 2015. PMID: 25822914 Free article.
182 results