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Coxsackievirus B1 infections are associated with the initiation of insulin-driven autoimmunity that progresses to type 1 diabetes.
Sioofy-Khojine AB, Lehtonen J, Nurminen N, Laitinen OH, Oikarinen S, Huhtala H, Pakkanen O, Ruokoranta T, Hankaniemi MM, Toppari J, Vähä-Mäkilä M, Ilonen J, Veijola R, Knip M, Hyöty H. Sioofy-Khojine AB, et al. Among authors: pakkanen o. Diabetologia. 2018 May;61(5):1193-1202. doi: 10.1007/s00125-018-4561-y. Epub 2018 Feb 5. Diabetologia. 2018. PMID: 29404673
Coxsackievirus B1 is associated with induction of β-cell autoimmunity that portends type 1 diabetes.
Laitinen OH, Honkanen H, Pakkanen O, Oikarinen S, Hankaniemi MM, Huhtala H, Ruokoranta T, Lecouturier V, André P, Harju R, Virtanen SM, Lehtonen J, Almond JW, Simell T, Simell O, Ilonen J, Veijola R, Knip M, Hyöty H. Laitinen OH, et al. Among authors: pakkanen o. Diabetes. 2014 Feb;63(2):446-55. doi: 10.2337/db13-0619. Epub 2013 Aug 23. Diabetes. 2014. PMID: 23974921
Human enterovirus 71 strains in the background population and in hospital patients in Finland.
Honkanen H, Oikarinen S, Pakkanen O, Ruokoranta T, Pulkki MM, Laitinen OH, Tauriainen S, Korpela S, Lappalainen M, Vuorinen T, Haapala AM, Veijola R, Simell O, Ilonen J, Knip M, Hyöty H. Honkanen H, et al. Among authors: pakkanen o. J Clin Virol. 2013 Apr;56(4):348-53. doi: 10.1016/j.jcv.2012.11.018. Epub 2012 Dec 21. J Clin Virol. 2013. PMID: 23261080
Collagen prolyl 4-hydroxylase tetramers and dimers show identical decreases in Km values for peptide substrates with increasing chain length: mutation of one of the two catalytic sites in the tetramer inactivates the enzyme by more than half.
Kukkola L, Koivunen P, Pakkanen O, Page AP, Myllyharju J. Kukkola L, et al. Among authors: pakkanen o. J Biol Chem. 2004 Apr 30;279(18):18656-61. doi: 10.1074/jbc.M401514200. Epub 2004 Feb 25. J Biol Chem. 2004. PMID: 14985345 Free article.
Severe Extracellular Matrix Abnormalities and Chondrodysplasia in Mice Lacking Collagen Prolyl 4-Hydroxylase Isoenzyme II in Combination with a Reduced Amount of Isoenzyme I.
Aro E, Salo AM, Khatri R, Finnilä M, Miinalainen I, Sormunen R, Pakkanen O, Holster T, Soininen R, Prein C, Clausen-Schaumann H, Aszódi A, Tuukkanen J, Kivirikko KI, Schipani E, Myllyharju J. Aro E, et al. Among authors: pakkanen o. J Biol Chem. 2015 Jul 3;290(27):16964-78. doi: 10.1074/jbc.M115.662635. Epub 2015 May 22. J Biol Chem. 2015. PMID: 26001784 Free PMC article.
Prolyl 4-hydroxylation regulates Argonaute 2 stability.
Qi HH, Ongusaha PP, Myllyharju J, Cheng D, Pakkanen O, Shi Y, Lee SW, Peng J, Shi Y. Qi HH, et al. Among authors: pakkanen o. Nature. 2008 Sep 18;455(7211):421-4. doi: 10.1038/nature07186. Epub 2008 Aug 6. Nature. 2008. PMID: 18690212 Free PMC article.
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