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Interacting-heads motif has been conserved as a mechanism of myosin II inhibition since before the origin of animals.
Lee KH, Sulbarán G, Yang S, Mun JY, Alamo L, Pinto A, Sato O, Ikebe M, Liu X, Korn ED, Sarsoza F, Bernstein SI, Padrón R, Craig R. Lee KH, et al. Among authors: yang s. Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):E1991-E2000. doi: 10.1073/pnas.1715247115. Epub 2018 Feb 14. Proc Natl Acad Sci U S A. 2018. PMID: 29444861 Free PMC article.
Cryo-EM structure of the inhibited (10S) form of myosin II.
Yang S, Tiwari P, Lee KH, Sato O, Ikebe M, Padrón R, Craig R. Yang S, et al. Nature. 2020 Dec;588(7838):521-525. doi: 10.1038/s41586-020-3007-0. Epub 2020 Dec 2. Nature. 2020. PMID: 33268893 Free PMC article.
Drug Development.
Hou K, Ge P, Sawaya MR, Dolinsky JL, Yang Y, Jiang YX, Lutter L, Boyer D, Cheng X, Pi J, Zhang J, Lu J, Yang S, Yu Z, Feigon J, Eisenberg DS. Hou K, et al. Among authors: yang s. Alzheimers Dement. 2024 Dec;20 Suppl 6:e085001. doi: 10.1002/alz.085001. Alzheimers Dement. 2024. PMID: 39782496
Dementia Care Research and Psychosocial Factors.
Feng Y, Hou B, Klein A, O'Connor K, Chen J, Mondragón A, Yang S, Gonzalez-Hernandez G, Shen L. Feng Y, et al. Among authors: yang s. Alzheimers Dement. 2024 Dec;20 Suppl 4:e093035. doi: 10.1002/alz.093035. Alzheimers Dement. 2024. PMID: 39782292
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