Young JE - Search Results

1

Stabilizing the Retromer Complex in a Human Stem Cell Model of Alzheimer's Disease Reduces TAU Phosphorylation Independently of Amyloid Precursor Protein.

Young JE, Fong LK, Frankowski H, Petsko GA, Small SA, Goldstein LSB. Young JE, et al. Stem Cell Reports. 2018 Mar 13;10(3):1046-1058. doi: 10.1016/j.stemcr.2018.01.031. Epub 2018 Mar 1. Stem Cell Reports. 2018. PMID: 29503090 Free PMC article.

2

Somatic coding mutations in human induced pluripotent stem cells.

Gore A, Li Z, Fung HL, Young JE, Agarwal S, Antosiewicz-Bourget J, Canto I, Giorgetti A, Israel MA, Kiskinis E, Lee JH, Loh YH, Manos PD, Montserrat N, Panopoulos AD, Ruiz S, Wilbert ML, Yu J, Kirkness EF, Izpisua Belmonte JC, Rossi DJ, Thomson JA, Eggan K, Daley GQ, Goldstein LS, Zhang K. Gore A, et al. Among authors: young je. Nature. 2011 Mar 3;471(7336):63-7. doi: 10.1038/nature09805. Nature. 2011. PMID: 21368825 Free PMC article.

3

Alzheimer's disease in a dish: promises and challenges of human stem cell models.

Young JE, Goldstein LS. Young JE, et al. Hum Mol Genet. 2012 Oct 15;21(R1):R82-9. doi: 10.1093/hmg/dds319. Epub 2012 Aug 2. Hum Mol Genet. 2012. PMID: 22865875 Free PMC article. Review.

4

The presenilin-1 ΔE9 mutation results in reduced γ-secretase activity, but not total loss of PS1 function, in isogenic human stem cells.

Woodruff G, Young JE, Martinez FJ, Buen F, Gore A, Kinaga J, Li Z, Yuan SH, Zhang K, Goldstein LS. Woodruff G, et al. Among authors: young je. Cell Rep. 2013 Nov 27;5(4):974-85. doi: 10.1016/j.celrep.2013.10.018. Epub 2013 Nov 14. Cell Rep. 2013. PMID: 24239350 Free PMC article.

5

Polyglutamine-expanded androgen receptor interferes with TFEB to elicit autophagy defects in SBMA.

Cortes CJ, Miranda HC, Frankowski H, Batlevi Y, Young JE, Le A, Ivanov N, Sopher BL, Carromeu C, Muotri AR, Garden GA, La Spada AR. Cortes CJ, et al. Among authors: young je. Nat Neurosci. 2014 Sep;17(9):1180-9. doi: 10.1038/nn.3787. Epub 2014 Aug 10. Nat Neurosci. 2014. PMID: 25108912 Free PMC article.

6

Elucidating molecular phenotypes caused by the SORL1 Alzheimer's disease genetic risk factor using human induced pluripotent stem cells.

Young JE, Boulanger-Weill J, Williams DA, Woodruff G, Buen F, Revilla AC, Herrera C, Israel MA, Yuan SH, Edland SD, Goldstein LS. Young JE, et al. Cell Stem Cell. 2015 Apr 2;16(4):373-85. doi: 10.1016/j.stem.2015.02.004. Epub 2015 Mar 12. Cell Stem Cell. 2015. PMID: 25772071 Free PMC article.

7

Defective Transcytosis of APP and Lipoproteins in Human iPSC-Derived Neurons with Familial Alzheimer's Disease Mutations.

Woodruff G, Reyna SM, Dunlap M, Van Der Kant R, Callender JA, Young JE, Roberts EA, Goldstein LS. Woodruff G, et al. Among authors: young je. Cell Rep. 2016 Oct 11;17(3):759-773. doi: 10.1016/j.celrep.2016.09.034. Cell Rep. 2016. PMID: 27732852 Free PMC article.

8

Leptomeninges-Derived Induced Pluripotent Stem Cells and Directly Converted Neurons From Autopsy Cases With Varying Neuropathologic Backgrounds.

Rose SE, Frankowski H, Knupp A, Berry BJ, Martinez R, Dinh SQ, Bruner LT, Willis SL, Crane PK, Larson EB, Grabowski T, Darvas M, Keene CD, Young JE. Rose SE, et al. Among authors: young je. J Neuropathol Exp Neurol. 2018 May 1;77(5):353-360. doi: 10.1093/jnen/nly013. J Neuropathol Exp Neurol. 2018. PMID: 29474672 Free PMC article.

9

Full-length amyloid precursor protein regulates lipoprotein metabolism and amyloid-β clearance in human astrocytes.

Fong LK, Yang MM, Dos Santos Chaves R, Reyna SM, Langness VF, Woodruff G, Roberts EA, Young JE, Goldstein LSB. Fong LK, et al. Among authors: young je. J Biol Chem. 2018 Jul 20;293(29):11341-11357. doi: 10.1074/jbc.RA117.000441. Epub 2018 Jun 1. J Biol Chem. 2018. PMID: 29858247 Free PMC article.

10

Advances and Current Challenges Associated with the Use of Human Induced Pluripotent Stem Cells in Modeling Neurodegenerative Disease.

Berry BJ, Smith AST, Young JE, Mack DL. Berry BJ, et al. Among authors: young je. Cells Tissues Organs. 2018;205(5-6):331-349. doi: 10.1159/000493018. Epub 2018 Oct 9. Cells Tissues Organs. 2018. PMID: 30300891 Review.

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