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Page 1
Discovery of Hydrolysis-Resistant Isoindoline N-Acyl Amino Acid Analogues that Stimulate Mitochondrial Respiration.
Lin H, Long JZ, Roche AM, Svensson KJ, Dou FY, Chang MR, Strutzenberg T, Ruiz C, Cameron MD, Novick SJ, Berdan CA, Louie SM, Nomura DK, Spiegelman BM, Griffin PR, Kamenecka TM. Lin H, et al. Among authors: roche am. J Med Chem. 2018 Apr 12;61(7):3224-3230. doi: 10.1021/acs.jmedchem.8b00029. Epub 2018 Mar 22. J Med Chem. 2018. PMID: 29533650 Free PMC article.
Ablation of PM20D1 reveals N-acyl amino acid control of metabolism and nociception.
Long JZ, Roche AM, Berdan CA, Louie SM, Roberts AJ, Svensson KJ, Dou FY, Bateman LA, Mina AI, Deng Z, Jedrychowski MP, Lin H, Kamenecka TM, Asara JM, Griffin PR, Banks AS, Nomura DK, Spiegelman BM. Long JZ, et al. Among authors: roche am. Proc Natl Acad Sci U S A. 2018 Jul 17;115(29):E6937-E6945. doi: 10.1073/pnas.1803389115. Epub 2018 Jul 2. Proc Natl Acad Sci U S A. 2018. PMID: 29967167 Free PMC article.
Isthmin-1 is an adipokine that promotes glucose uptake and improves glucose tolerance and hepatic steatosis.
Jiang Z, Zhao M, Voilquin L, Jung Y, Aikio MA, Sahai T, Dou FY, Roche AM, Carcamo-Orive I, Knowles JW, Wabitsch M, Appel EA, Maikawa CL, Camporez JP, Shulman GI, Tsai L, Rosen ED, Gardner CD, Spiegelman BM, Svensson KJ. Jiang Z, et al. Among authors: roche am. Cell Metab. 2021 Sep 7;33(9):1836-1852.e11. doi: 10.1016/j.cmet.2021.07.010. Epub 2021 Aug 3. Cell Metab. 2021. PMID: 34348115 Free PMC article.
Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.
Kim H, Wrann CD, Jedrychowski M, Vidoni S, Kitase Y, Nagano K, Zhou C, Chou J, Parkman VA, Novick SJ, Strutzenberg TS, Pascal BD, Le PT, Brooks DJ, Roche AM, Gerber KK, Mattheis L, Chen W, Tu H, Bouxsein ML, Griffin PR, Baron R, Rosen CJ, Bonewald LF, Spiegelman BM. Kim H, et al. Among authors: roche am. Cell. 2018 Dec 13;175(7):1756-1768.e17. doi: 10.1016/j.cell.2018.10.025. Cell. 2018. PMID: 30550785 Free PMC article.
Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.
Kim H, Wrann CD, Jedrychowski M, Vidoni S, Kitase Y, Nagano K, Zhou C, Chou J, Parkman VA, Novick SJ, Strutzenberg TS, Pascal BD, Le PT, Brooks DJ, Roche AM, Gerber KK, Mattheis L, Chen W, Tu H, Bouxsein ML, Griffin PR, Baron R, Rosen CJ, Bonewald LF, Spiegelman BM. Kim H, et al. Among authors: roche am. Cell. 2019 Jul 11;178(2):507-508. doi: 10.1016/j.cell.2019.06.028. Cell. 2019. PMID: 31299203 Free PMC article. No abstract available.
Hyperleukocytosis in a neuroblastoma patient after treatment with natural killer T cells expressing a GD2-specific chimeric antigen receptor and IL-15.
Tian G, Courtney AN, Yu H, Bhar S, Xu X, Barragán GA, Martinez Amador C, Ghatwai N, Wood MS, Schady D, Montalbano A, Reddy S, Roche AM, de la Cerda D, Parsons DW, Di Pierro EJ, Bushman FD, Heczey A, Metelitsa LS. Tian G, et al. Among authors: roche am. J Immunother Cancer. 2025 Jan 11;13(1):e010156. doi: 10.1136/jitc-2024-010156. J Immunother Cancer. 2025. PMID: 39800376
Leucine zipper-based immunomagnetic purification of CAR T cells displaying multiple receptors.
James SE, Chen S, Ng BD, Fischman JS, Jahn L, Boardman AP, Rajagopalan A, Elias HK, Massa A, Manuele D, Nichols KB, Lazrak A, Lee N, Roche AM, McFarland AG, Petrichenko A, Everett JK, Bushman FD, Fei T, Kousa AI, Lemarquis AL, DeWolf S, Peled JU, Vardhana SA, Klebanoff CA, van den Brink MRM. James SE, et al. Among authors: roche am. Nat Biomed Eng. 2024 Dec;8(12):1592-1614. doi: 10.1038/s41551-024-01287-3. Epub 2024 Dec 23. Nat Biomed Eng. 2024. PMID: 39715901
Modulation of AAV transduction and integration targeting by topoisomerase poisons.
Kasimsetty A, Hwang Y, Everett JK, McFarland AG, Zolnoski SA, Lu T, Roche AM, Martínez-García PM, Sabatino DE, Bushman FD. Kasimsetty A, et al. Among authors: roche am. Mol Ther Methods Clin Dev. 2024 Oct 28;32(4):101364. doi: 10.1016/j.omtm.2024.101364. eCollection 2024 Dec 12. Mol Ther Methods Clin Dev. 2024. PMID: 39618424 Free PMC article.
Regulated GATA1 expression as a universal gene therapy for Diamond-Blackfan anemia.
Voit RA, Liao X, Caulier A, Antoszewski M, Cohen B, Armant M, Lu HY, Fleming TJ, Kamal E, Wahlster L, Roche AM, Everett JK, Petrichenko A, Huang MM, Clarke W, Myers KC, Forester C, Perez-Atayde A, Bushman FD, Pellin D, Shimamura A, Williams DA, Sankaran VG. Voit RA, et al. Among authors: roche am. Cell Stem Cell. 2025 Jan 2;32(1):38-52.e6. doi: 10.1016/j.stem.2024.10.012. Epub 2024 Nov 11. Cell Stem Cell. 2025. PMID: 39532107 Free PMC article.
167 results