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Sirolimus in patients with clinically active systemic lupus erythematosus resistant to, or intolerant of, conventional medications: a single-arm, open-label, phase 1/2 trial.
Lai ZW, Kelly R, Winans T, Marchena I, Shadakshari A, Yu J, Dawood M, Garcia R, Tily H, Francis L, Faraone SV, Phillips PE, Perl A. Lai ZW, et al. Lancet. 2018 Mar 24;391(10126):1186-1196. doi: 10.1016/S0140-6736(18)30485-9. Epub 2018 Mar 15. Lancet. 2018. PMID: 29551338 Free PMC article. Clinical Trial.
N-acetylcysteine reduces disease activity by blocking mammalian target of rapamycin in T cells from systemic lupus erythematosus patients: a randomized, double-blind, placebo-controlled trial.
Lai ZW, Hanczko R, Bonilla E, Caza TN, Clair B, Bartos A, Miklossy G, Jimah J, Doherty E, Tily H, Francis L, Garcia R, Dawood M, Yu J, Ramos I, Coman I, Faraone SV, Phillips PE, Perl A. Lai ZW, et al. Arthritis Rheum. 2012 Sep;64(9):2937-46. doi: 10.1002/art.34502. Arthritis Rheum. 2012. PMID: 22549432 Free PMC article. Clinical Trial.
Sirolimus for systemic lupus erythematosus - Authors' reply.
Perl A, Lai ZW, Kelly R, Faraone SV, Phillips PE. Perl A, et al. Among authors: lai zw. Lancet. 2018 Sep 1;392(10149):734. doi: 10.1016/S0140-6736(18)31794-X. Lancet. 2018. PMID: 30191826 No abstract available.
mTOR-dependent loss of PON1 secretion and antiphospholipid autoantibody production underlie autoimmunity-mediated cirrhosis in transaldolase deficiency.
Winans T, Oaks Z, Choudhary G, Patel A, Huang N, Faludi T, Krakko D, Nolan J, Lewis J, Blair S, Lai Z, Landas SK, Middleton F, Asara JM, Chung SK, Wyman B, Azadi P, Banki K, Perl A. Winans T, et al. J Autoimmun. 2023 Nov;140:103112. doi: 10.1016/j.jaut.2023.103112. Epub 2023 Sep 22. J Autoimmun. 2023. PMID: 37742509 Free PMC article.
Rab4A-directed endosome traffic shapes pro-inflammatory mitochondrial metabolism in T cells via mitophagy, CD98 expression, and kynurenine-sensitive mTOR activation.
Huang N, Winans T, Wyman B, Oaks Z, Faludi T, Choudhary G, Lai ZW, Lewis J, Beckford M, Duarte M, Krakko D, Patel A, Park J, Caza T, Sadeghzadeh M, Morel L, Haas M, Middleton F, Banki K, Perl A. Huang N, et al. Among authors: lai zw. Nat Commun. 2024 Mar 22;15(1):2598. doi: 10.1038/s41467-024-46441-2. Nat Commun. 2024. PMID: 38519468 Free PMC article.
82 results