Qian G - Search Results

1

Monocyte chemotactic protein-induced protein-1 enhances DR5 degradation and negatively regulates DR5 activation-induced apoptosis through its deubiquitinase function.

Oh YT, Qian G, Deng J, Sun SY. Oh YT, et al. Among authors: qian g. Oncogene. 2018 Jun;37(25):3415-3425. doi: 10.1038/s41388-018-0200-9. Epub 2018 Mar 19. Oncogene. 2018. PMID: 29551769

2

Inhibition of mTOR complex 1/p70 S6 kinase signaling elevates PD-L1 levels in human cancer cells through enhancing protein stabilization accompanied with enhanced β-TrCP degradation.

Deng L, Qian G, Zhang S, Zheng H, Fan S, Lesinski GB, Owonikoko TK, Ramalingam SS, Sun SY. Deng L, et al. Among authors: qian g. Oncogene. 2019 Aug;38(35):6270-6282. doi: 10.1038/s41388-019-0877-4. Epub 2019 Jul 17. Oncogene. 2019. PMID: 31316145

3

Rictor, an essential component of mTOR complex 2, undergoes caspase-mediated cleavage during apoptosis induced by multiple stimuli.

Zhao L, Zhu L, Oh YT, Qian G, Chen Z, Sun SY. Zhao L, et al. Among authors: qian g. Apoptosis. 2021 Jun;26(5-6):338-347. doi: 10.1007/s10495-021-01676-y. Epub 2021 Apr 27. Apoptosis. 2021. PMID: 33905036

4

Overcoming Acquired Resistance to AZD9291, A Third-Generation EGFR Inhibitor, through Modulation of MEK/ERK-Dependent Bim and Mcl-1 Degradation.

Shi P, Oh YT, Deng L, Zhang G, Qian G, Zhang S, Ren H, Wu G, Legendre B Jr, Anderson E, Ramalingam SS, Owonikoko TK, Chen M, Sun SY. Shi P, et al. Among authors: qian g. Clin Cancer Res. 2017 Nov 1;23(21):6567-6579. doi: 10.1158/1078-0432.CCR-17-1574. Epub 2017 Aug 1. Clin Cancer Res. 2017. PMID: 28765329 Free PMC article.

5

Co-inhibition of BET and proteasome enhances ER stress and Bim-dependent apoptosis with augmented cancer therapeutic efficacy.

Qian G, Yao W, Zhang S, Bajpai R, Hall WD, Shanmugam M, Lonial S, Sun SY. Qian G, et al. Cancer Lett. 2018 Oct 28;435:44-54. doi: 10.1016/j.canlet.2018.07.033. Epub 2018 Jul 29. Cancer Lett. 2018. PMID: 30059709

6

The Third-Generation EGFR Inhibitor, Osimertinib, Promotes c-FLIP Degradation, Enhancing Apoptosis Including TRAIL-Induced Apoptosis in NSCLC Cells with Activating EGFR Mutations.

Shi P, Zhang S, Zhu L, Qian G, Ren H, Ramalingam SS, Chen M, Sun SY. Shi P, et al. Among authors: qian g. Transl Oncol. 2019 May;12(5):705-713. doi: 10.1016/j.tranon.2019.02.006. Epub 2019 Mar 9. Transl Oncol. 2019. PMID: 30856555 Free PMC article.

7

mTORC2 Suppresses GSK3-Dependent Snail Degradation to Positively Regulate Cancer Cell Invasion and Metastasis.

Zhang S, Qian G, Zhang QQ, Yao Y, Wang D, Chen ZG, Wang LJ, Chen M, Sun SY. Zhang S, et al. Among authors: qian g. Cancer Res. 2019 Jul 15;79(14):3725-3736. doi: 10.1158/0008-5472.CAN-19-0180. Epub 2019 May 29. Cancer Res. 2019. PMID: 31142514

8

ERK inhibition effectively overcomes acquired resistance of epidermal growth factor receptor-mutant non-small cell lung cancer cells to osimertinib.

Li Y, Zang H, Qian G, Owonikoko TK, Ramalingam SR, Sun SY. Li Y, et al. Among authors: qian g. Cancer. 2020 Mar 15;126(6):1339-1350. doi: 10.1002/cncr.32655. Epub 2019 Dec 10. Cancer. 2020. PMID: 31821539 Free PMC article.

9

Membrane-Associated RING-CH 8 Functions as a Novel PD-L1 E3 Ligase to Mediate PD-L1 Degradation Induced by EGFR Inhibitors.

Qian G, Guo J, Vallega KA, Hu C, Chen Z, Deng Y, Wang Q, Fan S, Ramalingam SS, Owonikoko TK, Wei W, Sun SY. Qian G, et al. Mol Cancer Res. 2021 Oct;19(10):1622-1634. doi: 10.1158/1541-7786.MCR-21-0147. Epub 2021 Jun 28. Mol Cancer Res. 2021. PMID: 34183449 Free PMC article.

10

Overcoming acquired resistance of epidermal growth factor receptor-mutant non-small cell lung cancer cells to osimertinib by combining osimertinib with the histone deacetylase inhibitor panobinostat (LBH589).

Zang H, Qian G, Zong D, Fan S, Owonikoko TK, Ramalingam SS, Sun SY. Zang H, et al. Among authors: qian g. Cancer. 2020 Jan 1;126(9):2024-2033. doi: 10.1002/cncr.32744. Epub 2020 Jan 30. Cancer. 2020. PMID: 31999837 Free PMC article.

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