Steitz TA - Search Results

1

Ribosome-Targeting Antibiotics: Modes of Action, Mechanisms of Resistance, and Implications for Drug Design.

Lin J, Zhou D, Steitz TA, Polikanov YS, Gagnon MG. Lin J, et al. Among authors: steitz ta. Annu Rev Biochem. 2018 Jun 20;87:451-478. doi: 10.1146/annurev-biochem-062917-011942. Epub 2018 Mar 23. Annu Rev Biochem. 2018. PMID: 29570352 Free PMC article. Review.

2

Elements of ribosomal drug resistance and specificity.

Blaha GM, Polikanov YS, Steitz TA. Blaha GM, et al. Among authors: steitz ta. Curr Opin Struct Biol. 2012 Dec;22(6):750-8. doi: 10.1016/j.sbi.2012.07.016. Epub 2012 Sep 13. Curr Opin Struct Biol. 2012. PMID: 22981944 Free PMC article. Review.

3

The mechanism of inhibition of protein synthesis by the proline-rich peptide oncocin.

Roy RN, Lomakin IB, Gagnon MG, Steitz TA. Roy RN, et al. Among authors: steitz ta. Nat Struct Mol Biol. 2015 Jun;22(6):466-9. doi: 10.1038/nsmb.3031. Epub 2015 May 18. Nat Struct Mol Biol. 2015. PMID: 25984972 Free PMC article.

4

Antimicrobial peptides targeting bacterial ribosome.

Lomakin IB, Gagnon MG, Steitz TA. Lomakin IB, et al. Among authors: steitz ta. Oncotarget. 2015 Aug 7;6(22):18744-5. doi: 10.18632/oncotarget.5114. Oncotarget. 2015. PMID: 26300053 Free PMC article. No abstract available.

5

Structures of proline-rich peptides bound to the ribosome reveal a common mechanism of protein synthesis inhibition.

Gagnon MG, Roy RN, Lomakin IB, Florin T, Mankin AS, Steitz TA. Gagnon MG, et al. Among authors: steitz ta. Nucleic Acids Res. 2016 Mar 18;44(5):2439-50. doi: 10.1093/nar/gkw018. Epub 2016 Jan 24. Nucleic Acids Res. 2016. PMID: 26809677 Free PMC article.

6

Insights into RNA binding by the anticancer drug cisplatin from the crystal structure of cisplatin-modified ribosome.

Melnikov SV, Söll D, Steitz TA, Polikanov YS. Melnikov SV, et al. Among authors: steitz ta. Nucleic Acids Res. 2016 Jun 2;44(10):4978-87. doi: 10.1093/nar/gkw246. Epub 2016 Apr 13. Nucleic Acids Res. 2016. PMID: 27079977 Free PMC article.

7

Elongation factor 4 remodels the A-site tRNA on the ribosome.

Gagnon MG, Lin J, Steitz TA. Gagnon MG, et al. Among authors: steitz ta. Proc Natl Acad Sci U S A. 2016 May 3;113(18):4994-9. doi: 10.1073/pnas.1522932113. Epub 2016 Apr 18. Proc Natl Acad Sci U S A. 2016. PMID: 27092003 Free PMC article.

8

Structural basis for the rescue of stalled ribosomes: structure of YaeJ bound to the ribosome.

Gagnon MG, Seetharaman SV, Bulkley D, Steitz TA. Gagnon MG, et al. Among authors: steitz ta. Science. 2012 Mar 16;335(6074):1370-2. doi: 10.1126/science.1217443. Science. 2012. PMID: 22422986 Free PMC article.

9

How hibernation factors RMF, HPF, and YfiA turn off protein synthesis.

Polikanov YS, Blaha GM, Steitz TA. Polikanov YS, et al. Among authors: steitz ta. Science. 2012 May 18;336(6083):915-8. doi: 10.1126/science.1218538. Science. 2012. PMID: 22605777 Free PMC article.

10

The antibiotics dityromycin and GE82832 bind protein S12 and block EF-G-catalyzed translocation.

Bulkley D, Brandi L, Polikanov YS, Fabbretti A, O'Connor M, Gualerzi CO, Steitz TA. Bulkley D, et al. Among authors: steitz ta. Cell Rep. 2014 Jan 30;6(2):357-65. doi: 10.1016/j.celrep.2013.12.024. Epub 2014 Jan 9. Cell Rep. 2014. PMID: 24412368 Free PMC article.

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