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Page 1
Repurposing a Library of Human Cathepsin L Ligands: Identification of Macrocyclic Lactams as Potent Rhodesain and Trypanosoma brucei Inhibitors.
Giroud M, Dietzel U, Anselm L, Banner D, Kuglstatter A, Benz J, Blanc JB, Gaufreteau D, Liu H, Lin X, Stich A, Kuhn B, Schuler F, Kaiser M, Brun R, Schirmeister T, Kisker C, Diederich F, Haap W. Giroud M, et al. Among authors: kuhn b. J Med Chem. 2018 Apr 26;61(8):3350-3369. doi: 10.1021/acs.jmedchem.7b01869. Epub 2018 Apr 13. J Med Chem. 2018. PMID: 29590750
Fluorine in medicinal chemistry.
Böhm HJ, Banner D, Bendels S, Kansy M, Kuhn B, Müller K, Obst-Sander U, Stahl M. Böhm HJ, et al. Among authors: kuhn b. Chembiochem. 2004 May 3;5(5):637-43. doi: 10.1002/cbic.200301023. Chembiochem. 2004. PMID: 15122635 Review.
Synthesis and biological evaluation of fenobam analogs as mGlu5 receptor antagonists.
Jaeschke G, Porter R, Büttelmann B, Ceccarelli SM, Guba W, Kuhn B, Kolczewski S, Huwyler J, Mutel V, Peters JU, Ballard T, Prinssen E, Vieira E, Wichmann J, Spooren W. Jaeschke G, et al. Among authors: kuhn b. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1307-11. doi: 10.1016/j.bmcl.2006.12.033. Epub 2006 Dec 15. Bioorg Med Chem Lett. 2007. PMID: 17196387
1,3-disubstituted 4-aminopiperidines as useful tools in the optimization of the 2-aminobenzo[a]quinolizine dipeptidyl peptidase IV inhibitors.
Lübbers T, Böhringer M, Gobbi L, Hennig M, Hunziker D, Kuhn B, Löffler B, Mattei P, Narquizian R, Peters JU, Ruff Y, Wessel HP, Wyss P. Lübbers T, et al. Among authors: kuhn b. Bioorg Med Chem Lett. 2007 Jun 1;17(11):2966-70. doi: 10.1016/j.bmcl.2007.03.072. Epub 2007 Mar 25. Bioorg Med Chem Lett. 2007. PMID: 17418568
Design of novel aminopyrrolidine factor Xa inhibitors from a screening hit.
Zbinden KG, Anselm L, Banner DW, Benz J, Blasco F, Décoret G, Himber J, Kuhn B, Panday N, Ricklin F, Risch P, Schlatter D, Stahl M, Thomi S, Unger R, Haap W. Zbinden KG, et al. Among authors: kuhn b. Eur J Med Chem. 2009 Jul;44(7):2787-95. doi: 10.1016/j.ejmech.2008.12.025. Epub 2009 Jan 3. Eur J Med Chem. 2009. PMID: 19200624
538 results