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Metabotropic glutamate 2 receptor potentiators: receptor modulation, frequency-dependent synaptic activity, and efficacy in preclinical anxiety and psychosis model(s).
Johnson MP, Barda D, Britton TC, Emkey R, Hornback WJ, Jagdmann GE, McKinzie DL, Nisenbaum ES, Tizzano JP, Schoepp DD. Johnson MP, et al. Among authors: hornback wj. Psychopharmacology (Berl). 2005 Apr;179(1):271-83. doi: 10.1007/s00213-004-2099-9. Epub 2005 Feb 17. Psychopharmacology (Berl). 2005. PMID: 15717213
A novel class of positive allosteric modulators of AMPA receptors: design, synthesis, and structure-activity relationships of 3-biphenyl-4-yl-4-cyano-5-ethyl-1-methyl-1H-pyrrole-2-carboxylic acid, LY2059346.
Zarrinmayeh H, Tromiczak E, Zimmerman DM, Rankl N, Ho KH, Dominguez E, Castaño A, Escribano A, Fernandez C, Jimenez A, Hornback WJ, Nisenbaum ES. Zarrinmayeh H, et al. Among authors: hornback wj. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5203-6. doi: 10.1016/j.bmcl.2006.07.012. Epub 2006 Jul 25. Bioorg Med Chem Lett. 2006. PMID: 16872827
A novel class of AMPA receptor allosteric modulators. Part 1: design, synthesis, and SAR of 3-aryl-4-cyano-5-substituted-heteroaryl-2-carboxylic acid derivatives.
Fernandez MC, Castaño A, Dominguez E, Escribano A, Jiang D, Jimenez A, Hong E, Hornback WJ, Nisenbaum ES, Rankl N, Tromiczak E, Vaught G, Zarrinmayeh H, Zimmerman DM. Fernandez MC, et al. Among authors: hornback wj. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5057-61. doi: 10.1016/j.bmcl.2006.07.035. Epub 2006 Aug 1. Bioorg Med Chem Lett. 2006. PMID: 16879964
12 results