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Apolipoprotein A-IV binds αIIbβ3 integrin and inhibits thrombosis.
Xu XR, Wang Y, Adili R, Ju L, Spring CM, Jin JW, Yang H, Neves MAD, Chen P, Yang Y, Lei X, Chen Y, Gallant RC, Xu M, Zhang H, Song J, Ke P, Zhang D, Carrim N, Yu SY, Zhu G, She YM, Cyr T, Fu W, Liu G, Connelly PW, Rand ML, Adeli K, Freedman J, Lee JE, Tso P, Marchese P, Davidson WS, Jackson SP, Zhu C, Ruggeri ZM, Ni H. Xu XR, et al. Among authors: chen p, chen y. Nat Commun. 2018 Sep 6;9(1):3608. doi: 10.1038/s41467-018-05806-0. Nat Commun. 2018. PMID: 30190457 Free PMC article.
Humanized GPIbα-von Willebrand factor interaction in the mouse.
Kanaji S, Orje JN, Kanaji T, Kamikubo Y, Morodomi Y, Chen Y, Zarpellon A, Eberhardt J, Forli S, Fahs SA, Sood R, Haberichter SL, Montgomery RR, Ruggeri ZM. Kanaji S, et al. Among authors: chen y. Blood Adv. 2018 Oct 9;2(19):2522-2532. doi: 10.1182/bloodadvances.2018023507. Blood Adv. 2018. PMID: 30287479 Free PMC article.
The integrin PSI domain has an endogenous thiol isomerase function and is a novel target for antiplatelet therapy.
Zhu G, Zhang Q, Reddy EC, Carrim N, Chen Y, Xu XR, Xu M, Wang Y, Hou Y, Ma L, Li Y, Rui M, Petruzziello-Pellegrini TN, Lavalle C, Stratton TW, Lei X, Adili R, Chen P, Zhu C, Wilkins JA, Hynes RO, Freedman J, Ni H. Zhu G, et al. Among authors: chen p, chen y. Blood. 2017 Mar 30;129(13):1840-1854. doi: 10.1182/blood-2016-07-729400. Epub 2017 Jan 25. Blood. 2017. PMID: 28122739 Free PMC article.
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