Seymour A - Search Results

1

Low Seroprevalence of Neutralizing Antibodies Targeting Two Clade F AAV in Humans.

Ellsworth JL, O'Callaghan M, Rubin H, Seymour A. Ellsworth JL, et al. Among authors: seymour a. Hum Gene Ther Clin Dev. 2018 Mar;29(1):60-67. doi: 10.1089/humc.2017.239. Hum Gene Ther Clin Dev. 2018. PMID: 29624457

2

Clade F AAVHSCs cross the blood brain barrier and transduce the central nervous system in addition to peripheral tissues following intravenous administration in nonhuman primates.

Ellsworth JL, Gingras J, Smith LJ, Rubin H, Seabrook TA, Patel K, Zapata N, Olivieri K, O'Callaghan M, Chlipala E, Morales P, Seymour A. Ellsworth JL, et al. Among authors: seymour a. PLoS One. 2019 Nov 26;14(11):e0225582. doi: 10.1371/journal.pone.0225582. eCollection 2019. PLoS One. 2019. PMID: 31770409 Free PMC article.

3

Sustained Correction of a Murine Model of Phenylketonuria following a Single Intravenous Administration of AAVHSC15-PAH.

Ahmed SS, Rubin H, Wang M, Faulkner D, Sengooba A, Dollive SN, Avila N, Ellsworth JL, Lamppu D, Lobikin M, Lotterhand J, Adamson-Small L, Wright T, Seymour A, Francone OL. Ahmed SS, et al. Among authors: seymour a. Mol Ther Methods Clin Dev. 2020 Mar 13;17:568-580. doi: 10.1016/j.omtm.2020.03.009. eCollection 2020 Jun 12. Mol Ther Methods Clin Dev. 2020. PMID: 32258219 Free PMC article.

4

Natural variations in AAVHSC16 significantly reduce liver tropism and maintain broad distribution to periphery and CNS.

Smith LJ, Schulman LA, Smith S, Van Lieshout L, Barnes CM, Behmoiras L, Scarpitti M, Kivaa M, Duong KL, Benard LO, Ellsworth JL, Avila N, Faulkner D, Hayes A, Lotterhand J, Rivas JI, Sengooba AV, Tzianabos A, Seymour AB, Francone OL. Smith LJ, et al. Among authors: seymour ab. Mol Ther Methods Clin Dev. 2022 Jun 30;26:224-238. doi: 10.1016/j.omtm.2022.06.013. eCollection 2022 Sep 8. Mol Ther Methods Clin Dev. 2022. PMID: 35859693 Free PMC article.

5

Molecular characterization of precise in vivo targeted gene integration in human cells using AAVHSC15.

Chen HM, Resendes R, Ghodssi A, Sookiasian D, Tian M, Dollive S, Adamson-Small L, Avila N, Tazearslan C, Thompson JF, Ellsworth JL, Francone O, Seymour A, Wright JB. Chen HM, et al. Among authors: seymour a. PLoS One. 2020 May 26;15(5):e0233373. doi: 10.1371/journal.pone.0233373. eCollection 2020. PLoS One. 2020. PMID: 32453743 Free PMC article.

6

5-year retrospective analysis of patients with phenylketonuria (PKU) and hyperphenylalaninemia treated at two specialized clinics.

Levy H, Lamppu D, Anastosoaie V, Baker JL, DiBona K, Hawthorne S, Lindenberger J, Kinch D, Seymour A, McIlduff M, Watling S, Vockley J. Levy H, et al. Among authors: seymour a. Mol Genet Metab. 2020 Mar;129(3):177-185. doi: 10.1016/j.ymgme.2019.12.007. Epub 2019 Dec 10. Mol Genet Metab. 2020. PMID: 31883647 Free article.

7

Association between single-nucleotide polymorphisms in the endothelial lipase (LIPG) gene and high-density lipoprotein cholesterol levels.

Mank-Seymour AR, Durham KL, Thompson JF, Seymour AB, Milos PM. Mank-Seymour AR, et al. Biochim Biophys Acta. 2004 Feb 27;1636(1):40-6. doi: 10.1016/j.bbalip.2003.12.001. Biochim Biophys Acta. 2004. PMID: 14984737

8

Application of pooled genotyping to scan candidate regions for association with HDL cholesterol levels.

Hinds DA, Seymour AB, Durham LK, Banerjee P, Ballinger DG, Milos PM, Cox DR, Thompson JF, Frazer KA. Hinds DA, et al. Among authors: seymour ab. Hum Genomics. 2004 Nov;1(6):421-34. doi: 10.1186/1479-7364-1-6-421. Hum Genomics. 2004. PMID: 15606997 Free PMC article.

9

siRNA off-target effects can be reduced at concentrations that match their individual potency.

Caffrey DR, Zhao J, Song Z, Schaffer ME, Haney SA, Subramanian RR, Seymour AB, Hughes JD. Caffrey DR, et al. Among authors: seymour ab. PLoS One. 2011;6(7):e21503. doi: 10.1371/journal.pone.0021503. Epub 2011 Jul 5. PLoS One. 2011. PMID: 21750714 Free PMC article.

10

Relation of increased prebeta-1 high-density lipoprotein levels to risk of coronary heart disease.

Guey LT, Pullinger CR, Ishida BY, O'Connor PM, Zellner C, Francone OL, Laramie JM, Naya-Vigne JM, Siradze KA, Deedwania P, Redberg RF, Frost PH, Seymour AB, Kane JP, Malloy MJ. Guey LT, et al. Among authors: seymour ab. Am J Cardiol. 2011 Aug 1;108(3):360-6. doi: 10.1016/j.amjcard.2011.03.054. Am J Cardiol. 2011. PMID: 21757044

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