Tesmer JJG - Search Results

1

Utilizing a structure-based docking approach to develop potent G protein-coupled receptor kinase (GRK) 2 and 5 inhibitors.

Waldschmidt HV, Bouley R, Kirchhoff PD, Lee P, Tesmer JJG, Larsen SD. Waldschmidt HV, et al. Among authors: tesmer jjg. Bioorg Med Chem Lett. 2018 May 15;28(9):1507-1515. doi: 10.1016/j.bmcl.2018.03.082. Epub 2018 Mar 30. Bioorg Med Chem Lett. 2018. PMID: 29627263 Free PMC article.

2

Structures of rhodopsin kinase in different ligand states reveal key elements involved in G protein-coupled receptor kinase activation.

Singh P, Wang B, Maeda T, Palczewski K, Tesmer JJ. Singh P, et al. J Biol Chem. 2008 May 16;283(20):14053-62. doi: 10.1074/jbc.M708974200. Epub 2008 Mar 13. J Biol Chem. 2008. PMID: 18339619 Free PMC article.

3

Assembly of high order G alpha q-effector complexes with RGS proteins.

Shankaranarayanan A, Thal DM, Tesmer VM, Roman DL, Neubig RR, Kozasa T, Tesmer JJ. Shankaranarayanan A, et al. J Biol Chem. 2008 Dec 12;283(50):34923-34. doi: 10.1074/jbc.M805860200. Epub 2008 Oct 20. J Biol Chem. 2008. PMID: 18936096 Free PMC article.

4

A surface of the kinase domain critical for the allosteric activation of G protein-coupled receptor kinases.

Huang CC, Yoshino-Koh K, Tesmer JJG. Huang CC, et al. Among authors: tesmer jjg. J Biol Chem. 2009 Jun 19;284(25):17206-17215. doi: 10.1074/jbc.M809544200. Epub 2009 Apr 13. J Biol Chem. 2009. PMID: 19364770 Free PMC article.

5

Structure of human G protein-coupled receptor kinase 2 in complex with the kinase inhibitor balanol.

Tesmer JJ, Tesmer VM, Lodowski DT, Steinhagen H, Huber J. Tesmer JJ, et al. J Med Chem. 2010 Feb 25;53(4):1867-70. doi: 10.1021/jm9017515. J Med Chem. 2010. PMID: 20128603 Free PMC article.

6

Molecular basis for activation of G protein-coupled receptor kinases.

Boguth CA, Singh P, Huang CC, Tesmer JJ. Boguth CA, et al. EMBO J. 2010 Oct 6;29(19):3249-59. doi: 10.1038/emboj.2010.206. Epub 2010 Aug 20. EMBO J. 2010. PMID: 20729810 Free PMC article.

7

Recognition in the face of diversity: interactions of heterotrimeric G proteins and G protein-coupled receptor (GPCR) kinases with activated GPCRs.

Huang CC, Tesmer JJG. Huang CC, et al. Among authors: tesmer jjg. J Biol Chem. 2011 Mar 11;286(10):7715-7721. doi: 10.1074/jbc.R109.051847. Epub 2011 Jan 3. J Biol Chem. 2011. PMID: 21199869 Free PMC article. Review.

8

Activation of G protein-coupled receptor kinase 1 involves interactions between its N-terminal region and its kinase domain.

Huang CC, Orban T, Jastrzebska B, Palczewski K, Tesmer JJ. Huang CC, et al. Biochemistry. 2011 Mar 22;50(11):1940-9. doi: 10.1021/bi101606e. Epub 2011 Feb 22. Biochemistry. 2011. PMID: 21265573 Free PMC article.

9

Molecular mechanism of selectivity among G protein-coupled receptor kinase 2 inhibitors.

Thal DM, Yeow RY, Schoenau C, Huber J, Tesmer JJ. Thal DM, et al. Mol Pharmacol. 2011 Aug;80(2):294-303. doi: 10.1124/mol.111.071522. Epub 2011 May 19. Mol Pharmacol. 2011. PMID: 21596927 Free PMC article.

10

Heterotrimeric G protein beta1gamma2 subunits change orientation upon complex formation with G protein-coupled receptor kinase 2 (GRK2) on a model membrane.

Boughton AP, Yang P, Tesmer VM, Ding B, Tesmer JJ, Chen Z. Boughton AP, et al. Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):E667-73. doi: 10.1073/pnas.1108236108. Epub 2011 Aug 29. Proc Natl Acad Sci U S A. 2011. PMID: 21876134 Free PMC article.

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