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Magnolol inhibits venous remodeling in mice.
Kuk H, Arnold C, Meyer R, Hecker M, Korff T. Kuk H, et al. Among authors: arnold c. Sci Rep. 2017 Dec 19;7(1):17820. doi: 10.1038/s41598-017-17910-0. Sci Rep. 2017. PMID: 29259201 Free PMC article.
Hypertension-evoked RhoA activity in vascular smooth muscle cells requires RGS5.
Arnold C, Demirel E, Feldner A, Genové G, Zhang H, Sticht C, Wieland T, Hecker M, Heximer S, Korff T. Arnold C, et al. FASEB J. 2018 Apr;32(4):2021-2035. doi: 10.1096/fj.201700384RR. Epub 2018 Jan 5. FASEB J. 2018. PMID: 29208700
Collectively, our findings underline that RhoA activation may depend on the restriction of G protein activity and identify RGS5 as a mechanosensitive regulatory protein that is required to promote the synthetic VSMC phenotype as a prerequisite for structural renovation of the art …
Collectively, our findings underline that RhoA activation may depend on the restriction of G protein activity and identify RGS5 as a mechano …
Genetic ablation of NFAT5/TonEBP in smooth muscle cells impairs flow- and pressure-induced arterial remodeling in mice.
Arnold C, Feldner A, Zappe M, Komljenovic D, De La Torre C, Ruzicka P, Hecker M, Neuhofer W, Korff T. Arnold C, et al. FASEB J. 2019 Mar;33(3):3364-3377. doi: 10.1096/fj.201801594R. Epub 2018 Nov 1. FASEB J. 2019. PMID: 30383452
Whereas originally described as a hypertonicity-responsive transcription factor, these findings identify NFAT5 as a novel molecular determinant of biomechanically induced phenotype changes of VSMCs and wall stress-induced arterial remodeling processes.-Arnold, C., F …
Whereas originally described as a hypertonicity-responsive transcription factor, these findings identify NFAT5 as a novel molecular determin …
NFAT5/TonEBP Limits Pulmonary Vascular Resistance in the Hypoxic Lung by Controlling Mitochondrial Reactive Oxygen Species Generation in Arterial Smooth Muscle Cells.
Laban H, Siegmund S, Zappe M, Trogisch FA, Heineke J, Torre C, Fisslthaler B, Arnold C, Lauryn J, Büttner M, Mogler C, Kato K, Adams RH, Kuk H, Fischer A, Hecker M, Kuebler WM, Korff T. Laban H, et al. Among authors: arnold c. Cells. 2021 Nov 24;10(12):3293. doi: 10.3390/cells10123293. Cells. 2021. PMID: 34943801 Free PMC article.
RGS5 promotes arterial growth during arteriogenesis.
Arnold C, Feldner A, Pfisterer L, Hödebeck M, Troidl K, Genové G, Wieland T, Hecker M, Korff T. Arnold C, et al. EMBO Mol Med. 2014 Aug;6(8):1075-89. doi: 10.15252/emmm.201403864. EMBO Mol Med. 2014. PMID: 24972930 Free PMC article.
1,631 results