Millen J - Search Results

1

Prevention of urinary albumin excretion in 6 month streptozocin-diabetic rats with the aldose reductase inhibitor tolrestat.

McCaleb ML, Sredy J, Millen J, Ackerman DM, Dvornik D. McCaleb ML, et al. Among authors: millen j. J Diabet Complications. 1988 Jan-Mar;2(1):16-8. doi: 10.1016/0891-6632(88)90020-7. J Diabet Complications. 1988. PMID: 2968349

2

Novel spirosuccinimides with incorporated isoindolone and benzisothiazole 1,1-dioxide moieties as aldose reductase inhibitors and antihyperglycemic agents.

Wrobel J, Dietrich A, Woolson SA, Millen J, McCaleb M, Harrison MC, Hohman TC, Sredy J, Sullivan D. Wrobel J, et al. Among authors: millen j. J Med Chem. 1992 Nov 27;35(24):4613-27. doi: 10.1021/jm00102a016. J Med Chem. 1992. PMID: 1469692

3

Syntheses of tolrestat analogues containing additional substituents in the ring and their evaluation as aldose reductase inhibitors. Identification of potent, orally active 2-fluoro derivatives.

Wrobel J, Millen J, Sredy J, Dietrich A, Gorham BJ, Malamas M, Kelly JM, Bauman JG, Harrison MC, Jones LR, et al. Wrobel J, et al. Among authors: millen j. J Med Chem. 1991 Aug;34(8):2504-20. doi: 10.1021/jm00112a029. J Med Chem. 1991. PMID: 1908522

4

Orally active aldose reductase inhibitors derived from bioisosteric substitutions on tolrestat.

Wrobel J, Millen J, Sredy J, Dietrich A, Kelly JM, Gorham BJ, Sestanj K. Wrobel J, et al. Among authors: millen j. J Med Chem. 1989 Nov;32(11):2493-500. doi: 10.1021/jm00131a012. J Med Chem. 1989. PMID: 2509709

5

Tolrestat pharmacokinetics in rat peripheral nerve.

Dvornik D, Millen J, Hicks DR, Kraml M. Dvornik D, et al. Among authors: millen j. J Diabetes Complications. 1994 Jan-Mar;8(1):18-26. doi: 10.1016/1056-8727(94)90006-x. J Diabetes Complications. 1994. PMID: 8167382

6

(Pyrimidinyloxy)acetic acids and pyrimidineacetic acids as a novel class of aldose reductase inhibitors.

Ellingboe J, Alessi T, Millen J, Sredy J, King A, Prusiewicz C, Guzzo F, VanEngen D, Bagli J. Ellingboe J, et al. Among authors: millen j. J Med Chem. 1990 Oct;33(10):2892-9. doi: 10.1021/jm00172a034. J Med Chem. 1990. PMID: 2120443

7

Computer-assisted design and synthesis of novel aldose reductase inhibitors.

Butera J, Bagli J, Doubleday W, Humber L, Treasurywala A, Loughney D, Sestanj K, Millen J, Sredy J. Butera J, et al. Among authors: millen j. J Med Chem. 1989 Apr;32(4):757-65. doi: 10.1021/jm00124a006. J Med Chem. 1989. PMID: 2539477

8

Novel spirosuccinimide aldose reductase inhibitors derived from isoquinoline-1,3-diones: 2-[(4-bromo-2-fluorophenyl)methyl]-6- fluorospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrone and congeners. 1.

Malamas MS, Hohman TC, Millen J. Malamas MS, et al. Among authors: millen j. J Med Chem. 1994 Jun 24;37(13):2043-58. doi: 10.1021/jm00039a017. J Med Chem. 1994. PMID: 8027986

9

Quinazolineacetic acids and related analogues as aldose reductase inhibitors.

Malamas MS, Millen J. Malamas MS, et al. Among authors: millen j. J Med Chem. 1991 Apr;34(4):1492-503. doi: 10.1021/jm00108a038. J Med Chem. 1991. PMID: 1901912

10

Induction of aldose reductase expression in rat kidney mesangial cells and Chinese hamster ovary cells under hypertonic conditions.

Kaneko M, Carper D, Nishimura C, Millen J, Bock M, Hohman TC. Kaneko M, et al. Among authors: millen j. Exp Cell Res. 1990 May;188(1):135-40. doi: 10.1016/0014-4827(90)90288-l. Exp Cell Res. 1990. PMID: 2109701

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