Fischer B - Search Results

1

Inhibition of nucleotide pyrophosphatase/phosphodiesterase 1: implications for developing a calcium pyrophosphate deposition disease modifying drug.

Danino O, Svetitsky S, Kenigsberg S, Levin A, Journo S, Gold A, Drexler M, Snir N, Elkayam O, Fischer B, Arad U. Danino O, et al. Among authors: fischer b. Rheumatology (Oxford). 2018 Aug 1;57(8):1472-1480. doi: 10.1093/rheumatology/key092. Rheumatology (Oxford). 2018. PMID: 29688536

2

Diadenosine 5',5''-(boranated)polyphosphonate analogues as selective nucleotide pyrophosphatase/phosphodiesterase inhibitors.

Eliahu S, Lecka J, Reiser G, Haas M, Bigonnesse F, Lévesque SA, Pelletier J, Sévigny J, Fischer B. Eliahu S, et al. Among authors: fischer b. J Med Chem. 2010 Dec 23;53(24):8485-97. doi: 10.1021/jm100597c. Epub 2010 Nov 22. J Med Chem. 2010. PMID: 21090681

3

Nucleoside 5'-phosphorothioate derivatives as oxidative stress protectants in PC12 cells.

Danino O, Grossman S, Fischer B. Danino O, et al. Among authors: fischer b. Nucleosides Nucleotides Nucleic Acids. 2013;32(7):333-53. doi: 10.1080/15257770.2013.789107. Nucleosides Nucleotides Nucleic Acids. 2013. PMID: 23742060

4

Highly efficient biocompatible neuroprotectants with dual activity as antioxidants and P2Y receptor agonists.

Azran S, Förster D, Danino O, Nadel Y, Reiser G, Fischer B. Azran S, et al. Among authors: fischer b. J Med Chem. 2013 Jun 27;56(12):4938-52. doi: 10.1021/jm400197m. Epub 2013 Jun 10. J Med Chem. 2013. PMID: 23751098

5

Nucleoside 5'-phosphorothioate derivatives are highly effective neuroprotectants.

Danino O, Giladi N, Grossman S, Fischer B. Danino O, et al. Among authors: fischer b. Biochem Pharmacol. 2014 Apr 1;88(3):384-92. doi: 10.1016/j.bcp.2014.02.001. Epub 2014 Feb 15. Biochem Pharmacol. 2014. PMID: 24548458

6

Highly potent and selective ectonucleotide pyrophosphatase/phosphodiesterase I inhibitors based on an adenosine 5'-(α or γ)-thio-(α,β- or β,γ)-methylenetriphosphate scaffold.

Nadel Y, Lecka J, Gilad Y, Ben-David G, Förster D, Reiser G, Kenigsberg S, Camden J, Weisman GA, Senderowitz H, Sévigny J, Fischer B. Nadel Y, et al. Among authors: fischer b. J Med Chem. 2014 Jun 12;57(11):4677-91. doi: 10.1021/jm500196c. Epub 2014 May 30. J Med Chem. 2014. PMID: 24846781 Free PMC article.

7

ATP-γ-S-(α,β-CH2) protects against oxidative stress and amyloid beta toxicity in neuronal culture.

Danino O, Grossman S, Fischer B. Danino O, et al. Among authors: fischer b. Biochem Biophys Res Commun. 2015 May 1;460(2):446-50. doi: 10.1016/j.bbrc.2015.03.053. Epub 2015 Mar 19. Biochem Biophys Res Commun. 2015. PMID: 25796332

8

Synthesis and structure-activity relationship of uracil nucleotide derivatives towards the identification of human P2Y6 receptor antagonists.

Meltzer D, Ethan O, Arguin G, Nadel Y, Danino O, Lecka J, Sévigny J, Gendron FP, Fischer B. Meltzer D, et al. Among authors: fischer b. Bioorg Med Chem. 2015 Sep 1;23(17):5764-73. doi: 10.1016/j.bmc.2015.07.004. Epub 2015 Jul 11. Bioorg Med Chem. 2015. PMID: 26233801

9

Identification of Highly Promising Antioxidants/Neuroprotectants Based on Nucleoside 5'-Phosphorothioate Scaffold. Synthesis, Activity, and Mechanisms of Action.

Azran S, Danino O, Förster D, Kenigsberg S, Reiser G, Dixit M, Singh V, Major DT, Fischer B. Azran S, et al. Among authors: fischer b. J Med Chem. 2015 Nov 12;58(21):8427-43. doi: 10.1021/acs.jmedchem.5b00575. Epub 2015 Oct 16. J Med Chem. 2015. PMID: 26447940

10

A Multifunctional Biocompatible Drug Candidate is Highly Effective in Delaying Pathological Signs of Alzheimer's Disease in 5XFAD Mice.

Segal-Gavish H, Danino O, Barhum Y, Ben-Zur T, Shai E, Varon D, Offen D, Fischer B. Segal-Gavish H, et al. Among authors: fischer b. J Alzheimers Dis. 2017;58(2):389-400. doi: 10.3233/JAD-161236. J Alzheimers Dis. 2017. PMID: 28453480

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