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Patient-iPSC-Derived Kidney Organoids Show Functional Validation of a Ciliopathic Renal Phenotype and Reveal Underlying Pathogenetic Mechanisms.
Forbes TA, Howden SE, Lawlor K, Phipson B, Maksimovic J, Hale L, Wilson S, Quinlan C, Ho G, Holman K, Bennetts B, Crawford J, Trnka P, Oshlack A, Patel C, Mallett A, Simons C, Little MH. Forbes TA, et al. Among authors: hale l. Am J Hum Genet. 2018 May 3;102(5):816-831. doi: 10.1016/j.ajhg.2018.03.014. Epub 2018 Apr 26. Am J Hum Genet. 2018. PMID: 29706353 Free PMC article.
Shining a Light on Alport Syndrome.
Hale LJ, Little MH. Hale LJ, et al. Cell Chem Biol. 2018 May 17;25(5):497-498. doi: 10.1016/j.chembiol.2018.05.001. Cell Chem Biol. 2018. PMID: 29775602 Free article.
Evaluation of variability in human kidney organoids.
Phipson B, Er PX, Combes AN, Forbes TA, Howden SE, Zappia L, Yen HJ, Lawlor KT, Hale LJ, Sun J, Wolvetang E, Takasato M, Oshlack A, Little MH. Phipson B, et al. Among authors: hale lj. Nat Methods. 2019 Jan;16(1):79-87. doi: 10.1038/s41592-018-0253-2. Epub 2018 Dec 20. Nat Methods. 2019. PMID: 30573816 Free PMC article.
Generating Kidney from Stem Cells.
Little MH, Hale LJ, Howden SE, Kumar SV. Little MH, et al. Annu Rev Physiol. 2019 Feb 10;81:335-357. doi: 10.1146/annurev-physiol-020518-114331. Annu Rev Physiol. 2019. PMID: 30742789 Review.
Cellular extrusion bioprinting improves kidney organoid reproducibility and conformation.
Lawlor KT, Vanslambrouck JM, Higgins JW, Chambon A, Bishard K, Arndt D, Er PX, Wilson SB, Howden SE, Tan KS, Li F, Hale LJ, Shepherd B, Pentoney S, Presnell SC, Chen AE, Little MH. Lawlor KT, et al. Nat Mater. 2021 Feb;20(2):260-271. doi: 10.1038/s41563-020-00853-9. Epub 2020 Nov 23. Nat Mater. 2021. PMID: 33230326 Free PMC article.
Insulin signaling to the glomerular podocyte is critical for normal kidney function.
Welsh GI, Hale LJ, Eremina V, Jeansson M, Maezawa Y, Lennon R, Pons DA, Owen RJ, Satchell SC, Miles MJ, Caunt CJ, McArdle CA, Pavenstädt H, Tavaré JM, Herzenberg AM, Kahn CR, Mathieson PW, Quaggin SE, Saleem MA, Coward RJM. Welsh GI, et al. Cell Metab. 2010 Oct 6;12(4):329-340. doi: 10.1016/j.cmet.2010.08.015. Cell Metab. 2010. PMID: 20889126 Free PMC article.
Insulin-like growth factors and kidney disease.
Bach LA, Hale LJ. Bach LA, et al. Am J Kidney Dis. 2015 Feb;65(2):327-36. doi: 10.1053/j.ajkd.2014.05.024. Epub 2014 Aug 21. Am J Kidney Dis. 2015. PMID: 25151409 Review.
725 results