Lu HR - Search Results

1

Cross-Site Reliability of Human Induced Pluripotent stem cell-derived Cardiomyocyte Based Safety Assays Using Microelectrode Arrays: Results from a Blinded CiPA Pilot Study.

Millard D, Dang Q, Shi H, Zhang X, Strock C, Kraushaar U, Zeng H, Levesque P, Lu HR, Guillon JM, Wu JC, Li Y, Luerman G, Anson B, Guo L, Clements M, Abassi YA, Ross J, Pierson J, Gintant G. Millard D, et al. Among authors: lu hr. Toxicol Sci. 2018 Aug 1;164(2):550-562. doi: 10.1093/toxsci/kfy110. Toxicol Sci. 2018. PMID: 29718449 Free PMC article.

2

Choice of cardiac tissue in vitro plays an important role in assessing the risk of drug-induced cardiac arrhythmias in human: beyond QT prolongation.

Lu HR, Vlaminckx E, Gallacher DJ. Lu HR, et al. J Pharmacol Toxicol Methods. 2008 Jan-Feb;57(1):1-8. doi: 10.1016/j.vascn.2007.06.005. Epub 2007 Jul 17. J Pharmacol Toxicol Methods. 2008. PMID: 17964190

3

Repolarization reserve determines drug responses in human pluripotent stem cell derived cardiomyocytes.

Braam SR, Tertoolen L, Casini S, Matsa E, Lu HR, Teisman A, Passier R, Denning C, Gallacher DJ, Towart R, Mummery CL. Braam SR, et al. Among authors: lu hr. Stem Cell Res. 2013 Jan;10(1):48-56. doi: 10.1016/j.scr.2012.08.007. Epub 2012 Sep 7. Stem Cell Res. 2013. PMID: 23089628 Free article.

4

High Throughput Measurement of Ca++ Dynamics in Human Stem Cell-Derived Cardiomyocytes by Kinetic Image Cytometery: A Cardiac Risk Assessment Characterization Using a Large Panel of Cardioactive and Inactive Compounds.

Lu HR, Whittaker R, Price JH, Vega R, Pfeiffer ER, Cerignoli F, Towart R, Gallacher DJ. Lu HR, et al. Toxicol Sci. 2015 Dec;148(2):503-16. doi: 10.1093/toxsci/kfv201. Epub 2015 Sep 9. Toxicol Sci. 2015. PMID: 26358003

5

Functional and Transcriptional Characterization of Histone Deacetylase Inhibitor-Mediated Cardiac Adverse Effects in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.

Kopljar I, Gallacher DJ, De Bondt A, Cougnaud L, Vlaminckx E, Van den Wyngaert I, Lu HR. Kopljar I, et al. Among authors: lu hr. Stem Cells Transl Med. 2016 May;5(5):602-12. doi: 10.5966/sctm.2015-0279. Epub 2016 Mar 31. Stem Cells Transl Med. 2016. PMID: 27034410 Free PMC article.

6

Chronic drug-induced effects on contractile motion properties and cardiac biomarkers in human induced pluripotent stem cell-derived cardiomyocytes.

Kopljar I, De Bondt A, Vinken P, Teisman A, Damiano B, Goeminne N, Van den Wyngaert I, Gallacher DJ, Lu HR. Kopljar I, et al. Among authors: lu hr. Br J Pharmacol. 2017 Nov;174(21):3766-3779. doi: 10.1111/bph.13713. Epub 2017 Feb 8. Br J Pharmacol. 2017. PMID: 28094846 Free PMC article.

7

Application of optical action potentials in human induced pluripotent stem cells-derived cardiomyocytes to predict drug-induced cardiac arrhythmias.

Lu HR, Hortigon-Vinagre MP, Zamora V, Kopljar I, De Bondt A, Gallacher DJ, Smith G. Lu HR, et al. J Pharmacol Toxicol Methods. 2017 Sep;87:53-67. doi: 10.1016/j.vascn.2017.05.001. Epub 2017 May 10. J Pharmacol Toxicol Methods. 2017. PMID: 28501647

8

Impact of calcium-sensitive dyes on the beating properties and pharmacological responses of human iPS-derived cardiomyocytes using the calcium transient assay.

Kopljar I, Hermans AN, Teisman A, Gallacher DJ, Lu HR. Kopljar I, et al. Among authors: lu hr. J Pharmacol Toxicol Methods. 2018 May-Jun;91:80-86. doi: 10.1016/j.vascn.2018.02.004. Epub 2018 Feb 6. J Pharmacol Toxicol Methods. 2018. PMID: 29421525

9

International Multisite Study of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Drug Proarrhythmic Potential Assessment.

Blinova K, Dang Q, Millard D, Smith G, Pierson J, Guo L, Brock M, Lu HR, Kraushaar U, Zeng H, Shi H, Zhang X, Sawada K, Osada T, Kanda Y, Sekino Y, Pang L, Feaster TK, Kettenhofen R, Stockbridge N, Strauss DG, Gintant G. Blinova K, et al. Among authors: lu hr. Cell Rep. 2018 Sep 25;24(13):3582-3592. doi: 10.1016/j.celrep.2018.08.079. Cell Rep. 2018. PMID: 30257217 Free PMC article.

10

Development of a Human iPSC Cardiomyocyte-Based Scoring System for Cardiac Hazard Identification in Early Drug Safety De-risking.

Kopljar I, Lu HR, Van Ammel K, Otava M, Tekle F, Teisman A, Gallacher DJ. Kopljar I, et al. Among authors: lu hr. Stem Cell Reports. 2018 Dec 11;11(6):1365-1377. doi: 10.1016/j.stemcr.2018.11.007. Stem Cell Reports. 2018. PMID: 30540961 Free PMC article.

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