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Glycoengineering HIV-1 Env creates 'supercharged' and 'hybrid' glycans to increase neutralizing antibody potency, breadth and saturation.
Crooks ET, Grimley SL, Cully M, Osawa K, Dekkers G, Saunders K, Rämisch S, Menis S, Schief WR, Doria-Rose N, Haynes B, Murrell B, Cale EM, Pegu A, Mascola JR, Vidarsson G, Binley JM. Crooks ET, et al. Among authors: murrell b. PLoS Pathog. 2018 May 2;14(5):e1007024. doi: 10.1371/journal.ppat.1007024. eCollection 2018 May. PLoS Pathog. 2018. PMID: 29718999 Free PMC article.
SARS-CoV-2 evolution in the Omicron era.
Roemer C, Sheward DJ, Hisner R, Gueli F, Sakaguchi H, Frohberg N, Schoenmakers J, Sato K, O'Toole Á, Rambaut A, Pybus OG, Ruis C, Murrell B, Peacock TP. Roemer C, et al. Among authors: murrell b. Nat Microbiol. 2023 Nov;8(11):1952-1959. doi: 10.1038/s41564-023-01504-w. Epub 2023 Oct 16. Nat Microbiol. 2023. PMID: 37845314 Review.
Optimized SMRT-UMI protocol produces highly accurate sequence datasets from diverse populations - application to HIV-1 quasispecies.
Westfall DH, Deng W, Pankow A, Murrell H, Chen L, Zhao H, Williamson C, Rolland M, Murrell B, Mullins JI. Westfall DH, et al. Among authors: murrell b, murrell h. bioRxiv [Preprint]. 2023 Feb 24:2023.02.23.529831. doi: 10.1101/2023.02.23.529831. bioRxiv. 2023. Update in: Virus Evol. 2024 Mar 02;10(1):veae019. doi: 10.1093/ve/veae019 PMID: 36865215 Free PMC article. Updated. Preprint.
Identification of broadly neutralizing antibody epitopes in the HIV-1 envelope glycoprotein using evolutionary models.
Lacerda M, Moore PL, Ngandu NK, Seaman M, Gray ES, Murrell B, Krishnamoorthy M, Nonyane M, Madiga M, Wibmer CK, Sheward D, Bailer RT, Gao H, Greene KM, Karim SS, Mascola JR, Korber BT, Montefiori DC, Morris L, Williamson C, Seoighe C; CAVD-NSDP Consortium. Lacerda M, et al. Among authors: murrell b. Virol J. 2013 Dec 2;10:347. doi: 10.1186/1743-422X-10-347. Virol J. 2013. PMID: 24295501 Free PMC article.
IDEPI: rapid prediction of HIV-1 antibody epitopes and other phenotypic features from sequence data using a flexible machine learning platform.
Hepler NL, Scheffler K, Weaver S, Murrell B, Richman DD, Burton DR, Poignard P, Smith DM, Kosakovsky Pond SL. Hepler NL, et al. Among authors: murrell b. PLoS Comput Biol. 2014 Sep 25;10(9):e1003842. doi: 10.1371/journal.pcbi.1003842. eCollection 2014 Sep. PLoS Comput Biol. 2014. PMID: 25254639 Free PMC article.
Broadly Neutralizing Antibody Responses in a Large Longitudinal Sub-Saharan HIV Primary Infection Cohort.
Landais E, Huang X, Havenar-Daughton C, Murrell B, Price MA, Wickramasinghe L, Ramos A, Bian CB, Simek M, Allen S, Karita E, Kilembe W, Lakhi S, Inambao M, Kamali A, Sanders EJ, Anzala O, Edward V, Bekker LG, Tang J, Gilmour J, Kosakovsky-Pond SL, Phung P, Wrin T, Crotty S, Godzik A, Poignard P. Landais E, et al. Among authors: murrell b. PLoS Pathog. 2016 Jan 14;12(1):e1005369. doi: 10.1371/journal.ppat.1005369. eCollection 2016 Jan. PLoS Pathog. 2016. PMID: 26766578 Free PMC article.
Early Antibody Lineage Diversification and Independent Limb Maturation Lead to Broad HIV-1 Neutralization Targeting the Env High-Mannose Patch.
MacLeod DT, Choi NM, Briney B, Garces F, Ver LS, Landais E, Murrell B, Wrin T, Kilembe W, Liang CH, Ramos A, Bian CB, Wickramasinghe L, Kong L, Eren K, Wu CY, Wong CH; IAVI Protocol C Investigators & The IAVI African HIV Research Network; Kosakovsky Pond SL, Wilson IA, Burton DR, Poignard P. MacLeod DT, et al. Among authors: murrell b. Immunity. 2016 May 17;44(5):1215-26. doi: 10.1016/j.immuni.2016.04.016. Immunity. 2016. PMID: 27192579 Free PMC article.
Antibody 10-1074 suppresses viremia in HIV-1-infected individuals.
Caskey M, Schoofs T, Gruell H, Settler A, Karagounis T, Kreider EF, Murrell B, Pfeifer N, Nogueira L, Oliveira TY, Learn GH, Cohen YZ, Lehmann C, Gillor D, Shimeliovich I, Unson-O'Brien C, Weiland D, Robles A, Kümmerle T, Wyen C, Levin R, Witmer-Pack M, Eren K, Ignacio C, Kiss S, West AP Jr, Mouquet H, Zingman BS, Gulick RM, Keler T, Bjorkman PJ, Seaman MS, Hahn BH, Fätkenheuer G, Schlesinger SJ, Nussenzweig MC, Klein F. Caskey M, et al. Among authors: murrell b. Nat Med. 2017 Feb;23(2):185-191. doi: 10.1038/nm.4268. Epub 2017 Jan 16. Nat Med. 2017. PMID: 28092665 Free PMC article. Clinical Trial.
Extra-epitopic hepatitis C virus polymorphisms confer resistance to broadly neutralizing antibodies by modulating binding to scavenger receptor B1.
El-Diwany R, Cohen VJ, Mankowski MC, Wasilewski LN, Brady JK, Snider AE, Osburn WO, Murrell B, Ray SC, Bailey JR. El-Diwany R, et al. Among authors: murrell b. PLoS Pathog. 2017 Feb 24;13(2):e1006235. doi: 10.1371/journal.ppat.1006235. eCollection 2017 Feb. PLoS Pathog. 2017. PMID: 28235087 Free PMC article.
123 results