Fructose-1,6-diphosphate inhibits viral replication by promoting the lysosomal degradation of HMGB1 and blocking the binding of HMGB1 to the viral genome.
Hu P, Li H, Ji Z, Jing W, Li Z, Yu S, Shan X, Cui Y, Wang B, Dong H, Zhou Y, Wang Z, Xiong H, Zhang X, Li HC, Wang J, Tang J, Wang T, Xie K, Liu Y, Zhu H, Yu Q.
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PLoS Pathog. 2024 Dec 18;20(12):e1012782. doi: 10.1371/journal.ppat.1012782. eCollection 2024 Dec.
PLoS Pathog. 2024.
PMID: 39693295
Free PMC article.