Cell free hemoglobin in the fetoplacental circulation: a novel cause of fetal growth restriction?
Brook A, Hoaksey A, Gurung R, Yoong EEC, Sneyd R, Baynes GC, Bischof H, Jones S, Higgins LE, Jones C, Greenwood SL, Jones RL, Gram M, Lang I, Desoye G, Myers J, Schneider H, Hansson SR, Crocker IP, Brownbill P.
Brook A, et al. Among authors: brownbill p.
FASEB J. 2018 Oct;32(10):5436-5446. doi: 10.1096/fj.201800264R. Epub 2018 May 3.
FASEB J. 2018.
PMID: 29723064
Clinical Trial.
During ex vivo placental perfusion, pathophysiological fHbF concentrations significantly increased fetal-side microcirculatory resistance ( P < 0.05). fHbF sequestered NO in acute and chronic exposure models ( P < 0.001), and fHbF-primed placental endothelial
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During ex vivo placental perfusion, pathophysiological fHbF concentrations significantly increased fetal-side microcirculatory resistance ( …