Inhibition of human microsomal PGE2 synthase-1 reduces seizure-induced increases of P-glycoprotein expression and activity at the blood-brain barrier.
Soldner ELB, Hartz AMS, Akanuma SI, Pekcec A, Doods H, Kryscio RJ, Hosoya KI, Bauer B.
Soldner ELB, et al. Among authors: pekcec a.
FASEB J. 2019 Dec;33(12):13966-13981. doi: 10.1096/fj.201901460RR. Epub 2019 Oct 22.
FASEB J. 2019.
PMID: 31638830
Free PMC article.
To test our hypothesis, we exposed isolated brain capillaries to glutamate ex vivo and used a combined in vivo-ex vivo approach by isolating brain capillaries from humanized mPGES-1 mice to study P-gp levels. ...Our data provide key signaling steps underlying seizure-induc …
To test our hypothesis, we exposed isolated brain capillaries to glutamate ex vivo and used a combined in vivo-ex vivo approach by is …