Houghton M - Search Results

1

A computational approach for predicting off-target toxicity of antiviral ribonucleoside analogues to mitochondrial RNA polymerase.

Freedman H, Winter P, Tuszynski J, Tyrrell DL, Houghton M. Freedman H, et al. Among authors: houghton m. J Biol Chem. 2018 Jun 22;293(25):9696-9705. doi: 10.1074/jbc.RA118.002588. Epub 2018 May 8. J Biol Chem. 2018. PMID: 29739852 Free PMC article.

2

Detailed computational study of the active site of the hepatitis C viral RNA polymerase to aid novel drug design.

Barakat KH, Law J, Prunotto A, Magee WC, Evans DH, Tyrrell DL, Tuszynski J, Houghton M. Barakat KH, et al. Among authors: houghton m. J Chem Inf Model. 2013 Nov 25;53(11):3031-43. doi: 10.1021/ci4003969. Epub 2013 Oct 24. J Chem Inf Model. 2013. PMID: 24116674

3

A Refined Model of the HCV NS5A protein bound to daclatasvir explains drug-resistant mutations and activity against divergent genotypes.

Barakat KH, Anwar-Mohamed A, Tuszynski JA, Robins MJ, Tyrrell DL, Houghton M. Barakat KH, et al. Among authors: houghton m. J Chem Inf Model. 2015 Feb 23;55(2):362-73. doi: 10.1021/ci400631n. Epub 2014 Apr 14. J Chem Inf Model. 2015. PMID: 24730573

4

A human ether-á-go-go-related (hERG) ion channel atomistic model generated by long supercomputer molecular dynamics simulations and its use in predicting drug cardiotoxicity.

Anwar-Mohamed A, Barakat KH, Bhat R, Noskov SY, Tyrrell DL, Tuszynski JA, Houghton M. Anwar-Mohamed A, et al. Among authors: houghton m. Toxicol Lett. 2014 Nov 4;230(3):382-92. doi: 10.1016/j.toxlet.2014.08.007. Epub 2014 Aug 13. Toxicol Lett. 2014. PMID: 25127758

5

Structure and Function of the Hepatitis C Virus Envelope Glycoproteins E1 and E2: Antiviral and Vaccine Targets.

Freedman H, Logan MR, Law JL, Houghton M. Freedman H, et al. Among authors: houghton m. ACS Infect Dis. 2016 Nov 11;2(11):749-762. doi: 10.1021/acsinfecdis.6b00110. Epub 2016 Aug 16. ACS Infect Dis. 2016. PMID: 27933781 Review.

6

Application of Molecular Dynamics Simulations to the Design of Nucleotide Inhibitors Binding to Norovirus Polymerase.

Freedman H, Kundu J, Tchesnokov EP, Law JLM, Nieman JA, Schinazi RF, Tyrrell DL, Gotte M, Houghton M. Freedman H, et al. Among authors: houghton m. J Chem Inf Model. 2020 Dec 28;60(12):6566-6578. doi: 10.1021/acs.jcim.0c00742. Epub 2020 Dec 1. J Chem Inf Model. 2020. PMID: 33259199 Free PMC article.

7

Computational determination of toxicity risks associated with a selection of approved drugs having demonstrated activity against COVID-19.

Aminpour M, Delgado WEM, Wacker S, Noskov S, Houghton M, Tyrrell DLJ, Tuszynski JA. Aminpour M, et al. Among authors: houghton m. BMC Pharmacol Toxicol. 2021 Oct 21;22(1):61. doi: 10.1186/s40360-021-00519-5. BMC Pharmacol Toxicol. 2021. PMID: 34674775 Free PMC article.

8

A computational model for overcoming drug resistance using selective dual-inhibitors for aurora kinase A and its T217D variant.

Barakat KH, Huzil JT, Jordan KE, Evangelinos C, Houghton M, Tuszynski J. Barakat KH, et al. Among authors: houghton m. Mol Pharm. 2013 Dec 2;10(12):4572-89. doi: 10.1021/mp4003893. Epub 2013 Nov 5. Mol Pharm. 2013. PMID: 24094068

9

Computational Prediction of the Heterodimeric and Higher-Order Structure of gpE1/gpE2 Envelope Glycoproteins Encoded by Hepatitis C Virus.

Freedman H, Logan MR, Hockman D, Koehler Leman J, Law JLM, Houghton M. Freedman H, et al. Among authors: houghton m. J Virol. 2017 Mar 29;91(8):e02309-16. doi: 10.1128/JVI.02309-16. Print 2017 Apr 15. J Virol. 2017. PMID: 28148799 Free PMC article.

10

A Recombinant Hepatitis C Virus Genotype 1a E1/E2 Envelope Glycoprotein Vaccine Elicits Antibodies That Differentially Neutralize Closely Related 2a Strains through Interactions of the N-Terminal Hypervariable Region 1 of E2 with Scavenger Receptor B1.

Johnson J, Freedman H, Logan M, Wong JAJ, Hockman D, Chen C, He J, Beard MR, Eyre NS, Baumert TF, Tyrrell DL, Law JLM, Houghton M. Johnson J, et al. Among authors: houghton m. J Virol. 2019 Oct 29;93(22):e00810-19. doi: 10.1128/JVI.00810-19. Print 2019 Nov 15. J Virol. 2019. PMID: 31462563 Free PMC article.

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