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Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species.
Iljina M, Hong L, Horrocks MH, Ludtmann MH, Choi ML, Hughes CD, Ruggeri FS, Guilliams T, Buell AK, Lee JE, Gandhi S, Lee SF, Bryant CE, Vendruscolo M, Knowles TPJ, Dobson CM, De Genst E, Klenerman D. Iljina M, et al. Among authors: hong l. BMC Biol. 2017 Jul 3;15(1):57. doi: 10.1186/s12915-017-0390-6. BMC Biol. 2017. PMID: 28673288 Free PMC article.
Measurement of Tau Filament Fragmentation Provides Insights into Prion-like Spreading.
Kundel F, Hong L, Falcon B, McEwan WA, Michaels TCT, Meisl G, Esteras N, Abramov AY, Knowles TJP, Goedert M, Klenerman D. Kundel F, et al. Among authors: hong l. ACS Chem Neurosci. 2018 Jun 20;9(6):1276-1282. doi: 10.1021/acschemneuro.8b00094. Epub 2018 Apr 8. ACS Chem Neurosci. 2018. PMID: 29590529 Free PMC article.
Direct Observation of Murine Prion Protein Replication in Vitro.
Sang JC, Meisl G, Thackray AM, Hong L, Ponjavic A, Knowles TPJ, Bujdoso R, Klenerman D. Sang JC, et al. Among authors: hong l. J Am Chem Soc. 2018 Nov 7;140(44):14789-14798. doi: 10.1021/jacs.8b08311. Epub 2018 Oct 23. J Am Chem Soc. 2018. PMID: 30351023 Free PMC article.
Modeling fibril fragmentation in real-time.
Tan P, Hong L. Tan P, et al. Among authors: hong l. J Chem Phys. 2013 Aug 28;139(8):084904. doi: 10.1063/1.4819025. J Chem Phys. 2013. PMID: 24007034
3,864 results