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Page 1
Xenoprotein engineering via synthetic libraries.
Gates ZP, Vinogradov AA, Quartararo AJ, Bandyopadhyay A, Choo ZN, Evans ED, Halloran KH, Mijalis AJ, Mong SK, Simon MD, Standley EA, Styduhar ED, Tasker SZ, Touti F, Weber JM, Wilson JL, Jamison TF, Pentelute BL. Gates ZP, et al. Among authors: styduhar ed. Proc Natl Acad Sci U S A. 2018 Jun 5;115(23):E5298-E5306. doi: 10.1073/pnas.1722633115. Epub 2018 May 21. Proc Natl Acad Sci U S A. 2018. PMID: 29784819 Free PMC article.
Nitrone Cycloadditions of 1,2-Cyclohexadiene.
Barber JS, Styduhar ED, Pham HV, McMahon TC, Houk KN, Garg NK. Barber JS, et al. Among authors: styduhar ed. J Am Chem Soc. 2016 Mar 2;138(8):2512-5. doi: 10.1021/jacs.5b13304. Epub 2016 Feb 18. J Am Chem Soc. 2016. PMID: 26854652 Free PMC article.
Total synthesis of (-)-N-methylwelwitindolinone C isothiocyanate.
Huters AD, Quasdorf KW, Styduhar ED, Garg NK. Huters AD, et al. Among authors: styduhar ed. J Am Chem Soc. 2011 Oct 12;133(40):15797-9. doi: 10.1021/ja206538k. Epub 2011 Aug 11. J Am Chem Soc. 2011. PMID: 21819133 Free PMC article.
Discovery of Novel Pyrazolopyrimidines as Potent, Selective, and Orally Bioavailable Inhibitors of ALK2.
Nguyen MH, Atasoylu O, Wu L, Kapilashrami K, Pusey M, Gallagher K, Lai CT, Zhao P, Barbosa J, Liu K, He C, Zhang C, Styduhar ED, Witten MR, Chen Y, Lin L, Yang YO, Covington M, Diamond S, Yeleswaram S, Yao W. Nguyen MH, et al. Among authors: styduhar ed. ACS Med Chem Lett. 2022 Jun 22;13(7):1159-1164. doi: 10.1021/acsmedchemlett.2c00206. eCollection 2022 Jul 14. ACS Med Chem Lett. 2022. PMID: 35859885 Free PMC article.
Discovery of Orally Bioavailable FGFR2/FGFR3 Dual Inhibitors via Structure-Guided Scaffold Repurposing Approach.
Nguyen MH, Ye HF, Xu Y, Truong L, Horsey A, Zhao P, Styduhar ED, Frascella M, Leffet L, Federowicz K, Behshad E, Wang A, Zhang K, Witten MR, Qi C, Jalluri R, Lai CT, Atasoylu O, Harris JJ, Hess R, Lin L, Zhang G, Covington M, Diamond S, Yao W, Vechorkin O. Nguyen MH, et al. Among authors: styduhar ed. ACS Med Chem Lett. 2023 Feb 28;14(3):312-318. doi: 10.1021/acsmedchemlett.3c00003. eCollection 2023 Mar 9. ACS Med Chem Lett. 2023. PMID: 36923909 Free PMC article.
Potent and Selective Biaryl Amide Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1).
Sokolsky A, Vechorkin O, Hummel JR, Styduhar ED, Wang A, Nguyen MH, Ye HF, Liu K, Zhang K, Pan J, Ye Q, Atasoylu O, Behshad E, He X, Conlen P, Stump K, Ye M, Diamond S, Covington M, Yeleswaram S, Yao W. Sokolsky A, et al. Among authors: styduhar ed. ACS Med Chem Lett. 2022 Dec 13;14(1):116-122. doi: 10.1021/acsmedchemlett.2c00241. eCollection 2023 Jan 12. ACS Med Chem Lett. 2022. PMID: 36655134 Free PMC article.