Menaldino D - Search Results

1

An NMDAR positive and negative allosteric modulator series share a binding site and are interconverted by methyl groups.

Perszyk R, Katzman BM, Kusumoto H, Kell SA, Epplin MP, Tahirovic YA, Moore RL, Menaldino D, Burger P, Liotta DC, Traynelis SF. Perszyk R, et al. Among authors: menaldino d. Elife. 2018 May 24;7:e34711. doi: 10.7554/eLife.34711. Elife. 2018. PMID: 29792594 Free PMC article.

2

Fumonisin toxicity and sphingolipid biosynthesis.

Merrill AH Jr, Wang E, Vales TR, Smith ER, Schroeder JJ, Menaldino DS, Alexander C, Crane HM, Xia J, Liotta DC, Meredith FI, Riley RT. Merrill AH Jr, et al. Among authors: menaldino ds. Adv Exp Med Biol. 1996;392:297-306. doi: 10.1007/978-1-4899-1379-1_25. Adv Exp Med Biol. 1996. PMID: 8850625 Review.

3

Identification of ammonium ion and 2,6-bis(omega-aminobutyl)- 3, 5-diiminopiperazine as endogenous factors that account for the "burst" of sphingosine upon changing the medium of J774 cells in culture.

Warden LA, Menaldino DS, Wilson T, Liotta DC, Smith ER, Merrill AH Jr. Warden LA, et al. Among authors: menaldino ds. J Biol Chem. 1999 Nov 26;274(48):33875-80. doi: 10.1074/jbc.274.48.33875. J Biol Chem. 1999. PMID: 10567348 Free article.

4

Sphingoid bases and de novo ceramide synthesis: enzymes involved, pharmacology and mechanisms of action.

Menaldino DS, Bushnev A, Sun A, Liotta DC, Symolon H, Desai K, Dillehay DL, Peng Q, Wang E, Allegood J, Trotman-Pruett S, Sullards MC, Merrill AH Jr. Menaldino DS, et al. Pharmacol Res. 2003 May;47(5):373-81. doi: 10.1016/s1043-6618(03)00054-9. Pharmacol Res. 2003. PMID: 12676511 Review.

5

Novel synthesis and biological evaluation of enigmols as therapeutic agents for treating prostate cancer.

Garnier-Amblard EC, Mays SG, Arrendale RF, Baillie MT, Bushnev AS, Culver DG, Evers TJ, Holt JJ, Howard RB, Liebeskind LS, Menaldino DS, Natchus MG, Petros JA, Ramaraju H, Reddy GP, Liotta DC. Garnier-Amblard EC, et al. ACS Med Chem Lett. 2011 Mar 25;2(6):438-43. doi: 10.1021/ml2000164. eCollection 2011 Jun 9. ACS Med Chem Lett. 2011. PMID: 24900327 Free PMC article.

6

Sphingolipid analogues inhibit development of malaria parasites.

Meyer EV, Holt JJ, Girard KR, Ballie MT, Bushnev AS, Lapp S, Menaldino DS, Arrendale RF, Reddy GP, Evers TJ, Howard RB, Culver DG, Liotta DC, Galinski MR, Natchus MG. Meyer EV, et al. ACS Med Chem Lett. 2011 Dec 6;3(1):43-7. doi: 10.1021/ml2002136. eCollection 2012 Jan 12. ACS Med Chem Lett. 2011. PMID: 24900369 Free PMC article.

7

Context-dependent GluN2B-selective inhibitors of NMDA receptor function are neuroprotective with minimal side effects.

Yuan H, Myers SJ, Wells G, Nicholson KL, Swanger SA, Lyuboslavsky P, Tahirovic YA, Menaldino DS, Ganesh T, Wilson LJ, Liotta DC, Snyder JP, Traynelis SF. Yuan H, et al. Neuron. 2015 Mar 18;85(6):1305-1318. doi: 10.1016/j.neuron.2015.02.008. Epub 2015 Feb 26. Neuron. 2015. PMID: 25728572 Free PMC article.

8

Discovery of a Fluorinated Enigmol Analog with Enhanced in Vivo Pharmacokinetic and Anti-Tumor Properties.

Miller EJ, Mays SG, Baillie MT, Howard RB, Culver DG, Saindane M, Pruett ST, Holt JJ, Menaldino DS, Evers TJ, Reddy GP, Arrendale RF, Natchus MG, Petros JA, Liotta DC. Miller EJ, et al. ACS Med Chem Lett. 2016 Mar 21;7(5):537-42. doi: 10.1021/acsmedchemlett.6b00113. eCollection 2016 May 12. ACS Med Chem Lett. 2016. PMID: 27190606 Free PMC article.

9

The Structure-Activity Relationship of a Tetrahydroisoquinoline Class of N-Methyl-d-Aspartate Receptor Modulators that Potentiates GluN2B-Containing N-Methyl-d-Aspartate Receptors.

Strong KL, Epplin MP, Bacsa J, Butch CJ, Burger PB, Menaldino DS, Traynelis SF, Liotta DC. Strong KL, et al. J Med Chem. 2017 Jul 13;60(13):5556-5585. doi: 10.1021/acs.jmedchem.7b00239. Epub 2017 Jun 26. J Med Chem. 2017. PMID: 28586221 Free PMC article.

10

A Novel Negative Allosteric Modulator Selective for GluN2C/2D-Containing NMDA Receptors Inhibits Synaptic Transmission in Hippocampal Interneurons.

Swanger SA, Vance KM, Acker TM, Zimmerman SS, DiRaddo JO, Myers SJ, Bundgaard C, Mosley CA, Summer SL, Menaldino DS, Jensen HS, Liotta DC, Traynelis SF. Swanger SA, et al. ACS Chem Neurosci. 2018 Feb 21;9(2):306-319. doi: 10.1021/acschemneuro.7b00329. Epub 2017 Nov 2. ACS Chem Neurosci. 2018. PMID: 29043770 Free PMC article.

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