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Cocaine Self-administration Alters Transcriptome-wide Responses in the Brain's Reward Circuitry.
Walker DM, Cates HM, Loh YE, Purushothaman I, Ramakrishnan A, Cahill KM, Lardner CK, Godino A, Kronman HG, Rabkin J, Lorsch ZS, Mews P, Doyle MA, Feng J, Labonté B, Koo JW, Bagot RC, Logan RW, Seney ML, Calipari ES, Shen L, Nestler EJ. Walker DM, et al. Among authors: purushothaman i. Biol Psychiatry. 2018 Dec 15;84(12):867-880. doi: 10.1016/j.biopsych.2018.04.009. Epub 2018 Apr 25. Biol Psychiatry. 2018. PMID: 29861096 Free PMC article.
In vivo imaging identifies temporal signature of D1 and D2 medium spiny neurons in cocaine reward.
Calipari ES, Bagot RC, Purushothaman I, Davidson TJ, Yorgason JT, Peña CJ, Walker DM, Pirpinias ST, Guise KG, Ramakrishnan C, Deisseroth K, Nestler EJ. Calipari ES, et al. Among authors: purushothaman i. Proc Natl Acad Sci U S A. 2016 Mar 8;113(10):2726-31. doi: 10.1073/pnas.1521238113. Epub 2016 Feb 1. Proc Natl Acad Sci U S A. 2016. PMID: 26831103 Free PMC article.
Circuit-wide Transcriptional Profiling Reveals Brain Region-Specific Gene Networks Regulating Depression Susceptibility.
Bagot RC, Cates HM, Purushothaman I, Lorsch ZS, Walker DM, Wang J, Huang X, Schlüter OM, Maze I, Peña CJ, Heller EA, Issler O, Wang M, Song WM, Stein JL, Liu X, Doyle MA, Scobie KN, Sun HS, Neve RL, Geschwind D, Dong Y, Shen L, Zhang B, Nestler EJ. Bagot RC, et al. Among authors: purushothaman i. Neuron. 2016 Jun 1;90(5):969-83. doi: 10.1016/j.neuron.2016.04.015. Epub 2016 May 12. Neuron. 2016. PMID: 27181059 Free PMC article.
Ketamine and Imipramine Reverse Transcriptional Signatures of Susceptibility and Induce Resilience-Specific Gene Expression Profiles.
Bagot RC, Cates HM, Purushothaman I, Vialou V, Heller EA, Yieh L, LaBonté B, Peña CJ, Shen L, Wittenberg GM, Nestler EJ. Bagot RC, et al. Among authors: purushothaman i. Biol Psychiatry. 2017 Feb 15;81(4):285-295. doi: 10.1016/j.biopsych.2016.06.012. Epub 2016 Jun 18. Biol Psychiatry. 2017. PMID: 27569543 Free PMC article.
Estrogen receptor α drives pro-resilient transcription in mouse models of depression.
Lorsch ZS, Loh YE, Purushothaman I, Walker DM, Parise EM, Salery M, Cahill ME, Hodes GE, Pfau ML, Kronman H, Hamilton PJ, Issler O, Labonté B, Symonds AE, Zucker M, Zhang TY, Meaney MJ, Russo SJ, Shen L, Bagot RC, Nestler EJ. Lorsch ZS, et al. Among authors: purushothaman i. Nat Commun. 2018 Mar 16;9(1):1116. doi: 10.1038/s41467-018-03567-4. Nat Commun. 2018. PMID: 29549264 Free PMC article.
Transcriptional and physiological adaptations in nucleus accumbens somatostatin interneurons that regulate behavioral responses to cocaine.
Ribeiro EA, Salery M, Scarpa JR, Calipari ES, Hamilton PJ, Ku SM, Kronman H, Purushothaman I, Juarez B, Heshmati M, Doyle M, Lardner C, Burek D, Strat A, Pirpinias S, Mouzon E, Han MH, Neve RL, Bagot RC, Kasarskis A, Koo JW, Nestler EJ. Ribeiro EA, et al. Among authors: purushothaman i. Nat Commun. 2018 Aug 8;9(1):3149. doi: 10.1038/s41467-018-05657-9. Nat Commun. 2018. PMID: 30089879 Free PMC article.
A novel role for E2F3b in regulating cocaine action in the prefrontal cortex.
Cates HM, Bagot RC, Heller EA, Purushothaman I, Lardner CK, Walker DM, Peña CJ, Neve RL, Shen L, Nestler EJ. Cates HM, et al. Among authors: purushothaman i. Neuropsychopharmacology. 2019 Mar;44(4):776-784. doi: 10.1038/s41386-018-0296-1. Epub 2018 Dec 14. Neuropsychopharmacology. 2019. PMID: 30552390 Free PMC article.
Sex Differences in Nucleus Accumbens Transcriptome Profiles Associated with Susceptibility versus Resilience to Subchronic Variable Stress.
Hodes GE, Pfau ML, Purushothaman I, Ahn HF, Golden SA, Christoffel DJ, Magida J, Brancato A, Takahashi A, Flanigan ME, Ménard C, Aleyasin H, Koo JW, Lorsch ZS, Feng J, Heshmati M, Wang M, Turecki G, Neve R, Zhang B, Shen L, Nestler EJ, Russo SJ. Hodes GE, et al. Among authors: purushothaman i. J Neurosci. 2015 Dec 16;35(50):16362-76. doi: 10.1523/JNEUROSCI.1392-15.2015. J Neurosci. 2015. PMID: 26674863 Free PMC article.
41 results