Goméz-Lechón MJ - Search Results

1

Predicting drug-induced cholestasis: preclinical models.

Petrov PD, Fernández-Murga ML, López-Riera M, Goméz-Lechón MJ, Castell JV, Jover R. Petrov PD, et al. Among authors: gomez lechon mj. Expert Opin Drug Metab Toxicol. 2018 Jul;14(7):721-738. doi: 10.1080/17425255.2018.1487399. Epub 2018 Jun 20. Expert Opin Drug Metab Toxicol. 2018. PMID: 29888962 Review.

2

Long-term and mechanistic evaluation of drug-induced liver injury in Upcyte human hepatocytes.

Tolosa L, Jiménez N, Pelechá M, Castell JV, Gómez-Lechón MJ, Donato MT. Tolosa L, et al. Among authors: gomez lechon mj. Arch Toxicol. 2019 Feb;93(2):519-532. doi: 10.1007/s00204-018-2349-y. Epub 2018 Nov 13. Arch Toxicol. 2019. PMID: 30426164

3

Hepatic cell lines for drug hepatotoxicity testing: limitations and strategies to upgrade their metabolic competence by gene engineering.

Donato MT, Jover R, Gómez-Lechón MJ. Donato MT, et al. Curr Drug Metab. 2013 Nov;14(9):946-68. doi: 10.2174/1389200211314090002. Curr Drug Metab. 2013. PMID: 24160292 Review.

4

A simple transcriptomic signature able to predict drug-induced hepatic steatosis.

Benet M, Moya M, Donato MT, Lahoz A, Hervás D, Guzmán C, Gómez-Lechón MJ, Castell JV, Jover R. Benet M, et al. Arch Toxicol. 2014 Apr;88(4):967-82. doi: 10.1007/s00204-014-1197-7. Epub 2014 Jan 28. Arch Toxicol. 2014. PMID: 24469900

5

High-content screening of drug-induced mitochondrial impairment in hepatic cells: effects of statins.

Tolosa L, Carmona A, Castell JV, Gómez-Lechón MJ, Donato MT. Tolosa L, et al. Arch Toxicol. 2015 Oct;89(10):1847-60. doi: 10.1007/s00204-014-1334-3. Epub 2014 Aug 27. Arch Toxicol. 2015. PMID: 25160661

6

Customised in vitro model to detect human metabolism-dependent idiosyncratic drug-induced liver injury.

Tolosa L, Jiménez N, Pérez G, Castell JV, Gómez-Lechón MJ, Donato MT. Tolosa L, et al. Among authors: gomez lechon mj. Arch Toxicol. 2018 Jan;92(1):383-399. doi: 10.1007/s00204-017-2036-4. Epub 2017 Jul 31. Arch Toxicol. 2018. PMID: 28762043 Free PMC article.

7

Advances in drug-induced cholestasis: Clinical perspectives, potential mechanisms and in vitro systems.

Fernández-Murga ML, Petrov PD, Conde I, Castell JV, Goméz-Lechón MJ, Jover R. Fernández-Murga ML, et al. Among authors: gomez lechon mj. Food Chem Toxicol. 2018 Oct;120:196-212. doi: 10.1016/j.fct.2018.07.017. Epub 2018 Jul 7. Food Chem Toxicol. 2018. PMID: 29990576 Review.

8

Human hepatocytes as a tool for studying toxicity and drug metabolism.

Gómez-Lechón MJ, Donato MT, Castell JV, Jover R. Gómez-Lechón MJ, et al. Curr Drug Metab. 2003 Aug;4(4):292-312. doi: 10.2174/1389200033489424. Curr Drug Metab. 2003. PMID: 12871046 Review.

9

Cell lines: a tool for in vitro drug metabolism studies.

Donato MT, Lahoz A, Castell JV, Gómez-Lechón MJ. Donato MT, et al. Curr Drug Metab. 2008 Jan;9(1):1-11. doi: 10.2174/138920008783331086. Curr Drug Metab. 2008. PMID: 18220566 Review.

10

Fluorescence-based assays for screening nine cytochrome P450 (P450) activities in intact cells expressing individual human P450 enzymes.

Donato MT, Jiménez N, Castell JV, Gómez-Lechón MJ. Donato MT, et al. Drug Metab Dispos. 2004 Jul;32(7):699-706. doi: 10.1124/dmd.32.7.699. Drug Metab Dispos. 2004. PMID: 15205384

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