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Human ACE2 transgenic pigs are susceptible to SARS-CoV-2 and develop COVID-19-like disease.
Chau LF, Lillico S, Opriessnig T, Blake R, Tardy L, Lee CH, Maxwell S, Warren C, Thornton E, Mclaughlin CL, McLachlan G, Tait-Burkard C, Fletcher S, Anderson S, Brown S, Gibbard L, Tzelos T, MacMillan-Christensen D, Baillie JK, Dorward DA, Griffiths DJ, Grey F. Chau LF, et al. Among authors: fletcher s. Nat Commun. 2025 Jan 17;16(1):766. doi: 10.1038/s41467-024-54615-1. Nat Commun. 2025. PMID: 39824810 Free PMC article.
The polypharmacy combination of the BCL-2 inhibitor venetoclax (VEN) and the FLT3 inhibitor gilteritinib (GIL) is more active in acute myeloid leukemia cells than novel polypharmacologic BCL-2/FLT3 VEN-GIL hybrid single-molecule inhibitors.
Goodis CC, Eberly C, Chan AM, Kim M, Lowe BD, Civin CI, Fletcher S. Goodis CC, et al. Among authors: fletcher s. Eur J Med Chem. 2024 Dec 22;285:117190. doi: 10.1016/j.ejmech.2024.117190. Online ahead of print. Eur J Med Chem. 2024. PMID: 39813774
Optimism for a global plastics treaty.
Fletcher S, Evans T. Fletcher S, et al. Science. 2025 Jan 10;387(6730):119. doi: 10.1126/science.adv2404. Epub 2025 Jan 9. Science. 2025. PMID: 39787233
1,532 results