Growth differentiation factor 11 worsens hepatocellular injury and liver regeneration after liver ischemia reperfusion injury.
Liu A, Dong W, Peng J, Dirsch O, Dahmen U, Fang H, Zhang C, Sun J.
Liu A, et al.
FASEB J. 2018 Sep;32(9):5186-5198. doi: 10.1096/fj.201800195R. Epub 2018 Apr 17.
FASEB J. 2018.
PMID: 29913561
Moreover, suppression of cell-cycle progression may be a key mechanism by which GDF11 inhibited hepatocyte regeneration. Collectively, rather than acting as a rejuvenating agent, GDF11 worsens hepatocellular injury and impairs liver regeneration after IRI.-Liu …
Moreover, suppression of cell-cycle progression may be a key mechanism by which GDF11 inhibited hepatocyte regeneration. Collectively …