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Euphol, a tetracyclic triterpene, from Euphorbia tirucalli induces autophagy and sensitizes temozolomide cytotoxicity on glioblastoma cells.
Silva VAO, Rosa MN, Miranda-Gonçalves V, Costa AM, Tansini A, Evangelista AF, Martinho O, Carloni AC, Jones C, Lima JP, Pianowski LF, Reis RM. Silva VAO, et al. Among authors: jones c. Invest New Drugs. 2019 Apr;37(2):223-237. doi: 10.1007/s10637-018-0620-y. Epub 2018 Jun 22. Invest New Drugs. 2019. PMID: 29931585
Loss of 5'-Methylthioadenosine Phosphorylase (MTAP) is Frequent in High-Grade Gliomas; Nevertheless, it is Not Associated with Higher Tumor Aggressiveness.
Menezes WP, Silva VAO, Gomes INF, Rosa MN, Spina MLC, Carloni AC, Alves ALV, Melendez M, Almeida GC, Silva LSD, Clara C, da Cunha IW, Hajj GNM, Jones C, Bidinotto LT, Reis RM. Menezes WP, et al. Among authors: jones c. Cells. 2020 Feb 20;9(2):492. doi: 10.3390/cells9020492. Cells. 2020. PMID: 32093414 Free PMC article.
The T-box transcription factor brachyury behaves as a tumor suppressor in gliomas.
Pinto F, Costa ÂM, Santos GC, Matsushita MM, Costa S, Silva VA, Miranda-Gonçalves V, Lopes CM, Clara CA, Becker AP, Neder L, Hajj GN, da Cunha IW, Jones C, Andrade RP, Reis RM. Pinto F, et al. Among authors: jones c. J Pathol. 2020 May;251(1):87-99. doi: 10.1002/path.5419. Epub 2020 Apr 4. J Pathol. 2020. PMID: 32154590
Loss of SPINT2 expression frequently occurs in glioma, leading to increased growth and invasion via MMP2.
Pereira MS, Celeiro SP, Costa ÂM, Pinto F, Popov S, de Almeida GC, Amorim J, Pires MM, Pinheiro C, Lopes JM, Honavar M, Costa P, Pimentel J, Jones C, Reis RM, Viana-Pereira M. Pereira MS, et al. Among authors: jones c. Cell Oncol (Dordr). 2020 Feb;43(1):107-121. doi: 10.1007/s13402-019-00475-7. Epub 2019 Nov 7. Cell Oncol (Dordr). 2020. PMID: 31701492
MGMT-independent temozolomide resistance in pediatric glioblastoma cells associated with a PI3-kinase-mediated HOX/stem cell gene signature.
Gaspar N, Marshall L, Perryman L, Bax DA, Little SE, Viana-Pereira M, Sharp SY, Vassal G, Pearson AD, Reis RM, Hargrave D, Workman P, Jones C. Gaspar N, et al. Among authors: jones c. Cancer Res. 2010 Nov 15;70(22):9243-52. doi: 10.1158/0008-5472.CAN-10-1250. Epub 2010 Oct 8. Cancer Res. 2010. PMID: 20935218 Free PMC article.
The long non-coding RNA HOTAIR is transcriptionally activated by HOXA9 and is an independent prognostic marker in patients with malignant glioma.
Xavier-Magalhães A, Gonçalves CS, Fogli A, Lourenço T, Pojo M, Pereira B, Rocha M, Lopes MC, Crespo I, Rebelo O, Tão H, Lima J, Moreira R, Pinto AA, Jones C, Reis RM, Costello JF, Arnaud P, Sousa N, Costa BM. Xavier-Magalhães A, et al. Among authors: jones c. Oncotarget. 2018 Feb 28;9(21):15740-15756. doi: 10.18632/oncotarget.24597. eCollection 2018 Mar 20. Oncotarget. 2018. PMID: 29644006 Free PMC article.
Copy Number Profiling of Brazilian Astrocytomas.
Bidinotto LT, Torrieri R, Mackay A, Almeida GC, Viana-Pereira M, Cruvinel-Carloni A, Spina ML, Campanella NC, Pereira de Menezes W, Clara CA, Becker AP, Jones C, Reis RM. Bidinotto LT, et al. Among authors: jones c. G3 (Bethesda). 2016 Jul 7;6(7):1867-78. doi: 10.1534/g3.116.029884. G3 (Bethesda). 2016. PMID: 27172220 Free PMC article.
Molecular Profiling of a Rare Rosette-Forming Glioneuronal Tumor Arising in the Spinal Cord.
Bidinotto LT, Scapulatempo-Neto C, Mackay A, de Almeida GC, Scheithauer BW, Berardinelli GN, Torrieri R, Clara CA, Feltrin LT, Viana-Pereira M, Varella-Garcia M, Jones C, Reis RM. Bidinotto LT, et al. Among authors: jones c. PLoS One. 2015 Sep 15;10(9):e0137690. doi: 10.1371/journal.pone.0137690. eCollection 2015. PLoS One. 2015. PMID: 26371886 Free PMC article.
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